We are analyzing https://link.springer.com/article/10.1007/s12253-018-0433-5.

Title:
The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications | Pathology & Oncology Research
Description:
The histone acetylation modifications (HAMs) influence a large number of cellular functions. They are mediated through histone acetyltransferase (HAT) and histone deacetylase (HDAC). Nowadays, people have realized that HAMs are crucial for development and prognosis of breast cancer. Investigations about abnormal HAMs in breast cancer focus on initiating molecular mechanisms in breast cancer development, identification of new biomarkers to predict breast cancer aggressiveness and the therapeutic potential. As HAMs are reversible, breast cancer may be treated by restoring HAMs to normal levels. Indeed, some HDAC inhibitors have been approved by the US Food and Drug Administration to treat certain cancers. Furthermore, HAT inhibitors, HAT activators and HDAC activators may also be used as drugs to treat breast cancer.
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Keywords {🔍}

cancer, breast, pubmed, article, histone, google, scholar, cas, deacetylase, central, inhibitor, hdac, cells, research, inhibitors, acetyltransferase, chen, journal, acetylation, epigenetic, cell, liu, expression, kim, wang, therapeutic, epigenetics, zhang, bmc, httpsdoiorgs, res, mol, privacy, cookies, content, modifications, guo, hams, oncol, apoptosis, zhao, suppresses, publish, search, development, treat, access, therapy, inhibition, plos,

Topics {✒️}

month download article/chapter meiying li & lisha li anti-histone acetyltransferase activity histone-modifying enzymes lsd1 histone acetylation modifications catechol-o-methyltransferase gene enhances anti-tumor effects foxo3-mediated bim1 expression histone deacetylase inhibitor suppresses lung metastasis histone deacetylase inhibitors full article pdf histone acetyltransferase p300 tamoxifen induces apoptosis breast cancer models breast cancer research breast cancer cells usage analysis boyd jr privacy choices/manage cookies histone deacetylases hdac1 small-molecule inhibitors glioma cell lines mrc-5 cell lines tumor cells correlate acetyltransferase p300 identified breast cancer development p53 protein acetylation breast cancer focus treat breast cancer male breast cancer breast cancer patients epigenetic therapy mediated transcriptional suppression de kruijf em high-throughput screening histone acetyltransferase suberoylanilide hydroxamic acid breast cancer progression 1186/s12858-014-0030-5z lee histone deacetylase histone deacetylase 3 article guo related subjects da silva ap dietary components targeting potent anticancer agents van hoesel aq goossens-beumer ij dekker-ensink ng

Questions {❓}

Kochan DZ, Kovalchuk O (2015) Circadian disruption and breast cancer: an epigenetic link?

Schema {🗺️}

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