We are analyzing https://link.springer.com/article/10.1186/s13578-020-00415-1.

Title:
A three layered histone epigenetics in breast cancer metastasis | Cell & Bioscience
Description:
Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases—the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

cancer, breast, pubmed, histone, google, scholar, article, cas, cell, central, metastasis, cells, dna, expression, protein, chromatin, haz, methylation, epigenetic, role, metastatic, found, macroha, dek, res, factor, transcription, patients, acetylation, chaperone, tumor, promoter, epigenetics, mol, wang, variant, modifications, biol, variants, aplf, hjurp, treatment, emt, implicated, tnbc, daxx, domain, region, level, fact,

Topics {✒️}

prb2/p130-e2f4/5-hdac1-suv39h1-p300 genotoxic nf-κb activation regulating pi3k/akt/mtor pathway estrogen-dependent c-juner protein prb2/p130 molecular complex article download pdf phospho-dependent molecular recognition c-myc gene involves pi3k/akt/mtor pathway activating cdh1/skp2/p27kip1 pathway methyl-β-cyclodextrin mmp3 meiosis-specific sliding clamp oxidative stress-mediated apoptosis mre11-rad50-nbn msh4 triple-negative breast cancer er-α negative mcf-7 endocrine-resistant breast cancer estrogen-dependent gene transcription adp-ribose recognition motifs possess er-α receptor polyadp ribose glycohydrase = parg trastuzumab-based adjuvant therapy targeting pi3k/akt pathway acidic c-terminal domain β-catenin activation mcf-10a cell line c-src signaling pathway pi3k/akt signaling pathways tgf-β pathway induction c-src causing cytoskeleton xrcc4 dna-damage scaffolds mineral dust-induced gene mediate anti-tumor efficacy replication-dependent histone isoforms normal mcf-10a cells αc-helix region hypoxia-inducible factor-1 methyl-β-cyclodextrin aprataxin-family fha domains c-myc-p300 complex phosphorylated h4 variant-h4s1ph breast cancer-induced osteoclastogenesis c-terminal helix acquired estrogen-independence chromatin state [open/closed] tnbc mda-mb-231 cells dna damage signalling c-terminal domain interacting big tumour size targeting histone-mediated pathways

Questions {❓}

At last, a predictive and prognostic marker for radiotherapy?
Histone methylation: dynamic or static?
One important aspect that is still not clear is whether epigenetic modifications are consequences of aberrations in epigenetic modifiers or they part of the cancer etiology?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A three layered histone epigenetics in breast cancer metastasis
         description:Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases—the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.
         datePublished:2020-03-30T00:00:00Z
         dateModified:2020-03-30T00:00:00Z
         pageStart:1
         pageEnd:23
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13578-020-00415-1
         keywords:
            Histone
            Variants
            Chaperone
            Modification
            Breast cancer
            Metastasis
            Cell Biology
            Microbiology
            Stem Cells
            Neurobiology
            Proteomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13578-020-00415-1/MediaObjects/13578_2020_415_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13578-020-00415-1/MediaObjects/13578_2020_415_Fig2_HTML.png
         isPartOf:
            name:Cell & Bioscience
            issn:
               2045-3701
            volumeNumber:10
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Debparna Nandy
               affiliation:
                     name:Rajiv Gandhi Centre for Biotechnology
                     address:
                        name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sruthy Manuraj Rajam
               affiliation:
                     name:Rajiv Gandhi Centre for Biotechnology
                     address:
                        name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Debasree Dutta
               url:http://orcid.org/0000-0003-2745-9180
               affiliation:
                     name:Rajiv Gandhi Centre for Biotechnology
                     address:
                        name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A three layered histone epigenetics in breast cancer metastasis
      description:Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases—the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.
      datePublished:2020-03-30T00:00:00Z
      dateModified:2020-03-30T00:00:00Z
      pageStart:1
      pageEnd:23
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13578-020-00415-1
      keywords:
         Histone
         Variants
         Chaperone
         Modification
         Breast cancer
         Metastasis
         Cell Biology
         Microbiology
         Stem Cells
         Neurobiology
         Proteomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13578-020-00415-1/MediaObjects/13578_2020_415_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13578-020-00415-1/MediaObjects/13578_2020_415_Fig2_HTML.png
      isPartOf:
         name:Cell & Bioscience
         issn:
            2045-3701
         volumeNumber:10
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Debparna Nandy
            affiliation:
                  name:Rajiv Gandhi Centre for Biotechnology
                  address:
                     name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sruthy Manuraj Rajam
            affiliation:
                  name:Rajiv Gandhi Centre for Biotechnology
                  address:
                     name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Debasree Dutta
            url:http://orcid.org/0000-0003-2745-9180
            affiliation:
                  name:Rajiv Gandhi Centre for Biotechnology
                  address:
                     name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cell & Bioscience
      issn:
         2045-3701
      volumeNumber:10
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Rajiv Gandhi Centre for Biotechnology
      address:
         name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
         type:PostalAddress
      name:Rajiv Gandhi Centre for Biotechnology
      address:
         name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
         type:PostalAddress
      name:Rajiv Gandhi Centre for Biotechnology
      address:
         name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Debparna Nandy
      affiliation:
            name:Rajiv Gandhi Centre for Biotechnology
            address:
               name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
               type:PostalAddress
            type:Organization
      name:Sruthy Manuraj Rajam
      affiliation:
            name:Rajiv Gandhi Centre for Biotechnology
            address:
               name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
               type:PostalAddress
            type:Organization
      name:Debasree Dutta
      url:http://orcid.org/0000-0003-2745-9180
      affiliation:
            name:Rajiv Gandhi Centre for Biotechnology
            address:
               name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
      name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
      name:Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India

External Links {🔗}(709)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Pace
Prism.js

CDN Services {📦}

Crossref
Pbgrd

6.63s.

LINK . SPRINGER . COM {}