
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Tumour exosome integrins determine organotropic metastasis - PMC
Description:
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with ...
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Keywords {🔍}
exosomes, cells, lung, metastasis, data, doi, cell, cancer, exosome, fig, itgβ, liver, extended, lut, pubmed, google, scholar, exosomal, tumour, metastatic, analysis, mice, breast, pmc, human, expression, experiments, integrin, article, uptake, representative, free, injected, injection, exosomepositive, nature, integrins, itgα, independent, organotropic, patients, analysed, labelled, imaging, organspecific, specific, protein, lines, mdamb, red,
Topics {✒️}
z-scored label-free quantification human cancer-cell-line-derived exosomes pan02-lit-derived exosomes pre-incubated bone-marrow-derived myeloid cells matrix-assisted laser desorption/ionization mda-mb-231 subline-derived exosomes organotropic cell-line-derived exosomes exosome-mediated organ-specific conditioning cancer-cell-derived exosomes localize preparing pre-metastatic niches bone-marrow-derived cell education pre-metastatic niche formation bxpc-3β5kd-derived exosome biodistribution pre-determine sample size beta4 integrin-regulated expression lc–ms/ms experiments 4175-lut-derived exosomes pre-incubated determine organ sites β4 integrin-dependent formation tumour-derived exosomes prepare pro-inflammatory s100 molecules lc/ms sample pretreatment organ-specific cells prepare formvar-coated slot grids organotropic cell-derived exosomes pro-angiogenic immune cells6 exosomal itgβ4-dependent manner anti-metastatic combination therapies circulating tumour-derived exosomes detect tumour-derived exosomes confer lung-metastatic behaviour pan02-lit-derived exosomes bone-tropic tumour cells mitogen-activated protein kinases nature abstract osteoclast-stimulating growth factors direct organ-specific colonization pre-designed taqman assays lc–ms/ms pancreatic cancer-derived exosomes exosome-inducible s100 molecules pmc beta search pan02-lit exosome adhesion identifying cell-intrinsic determinants bxpc-3-lit-derived exosomes patient organ-specific metastasis exogenous tumour-derived exosomes ecm-enriched cellular areas organ-specific resident cells bone-tropic exosomes expressed
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