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Topics {✒️}

yasushi sasaki & takashi tokino cysteine-rich ligand-binding domain age-related dna methylation month download article/chapter tousei ohmura & koichi hirata methylation-induced gene silencing multiple genetic alterations cdkn2/p16/mts1 gene detected cancer-specific methylation demethylating agent 5-aza-2′-deoxycytidine real-time pcr analysis increased beta-catenin levels bisulfite-pyrosequencing analysis confirmed p53-mediated cellular response activator protein-2alpha expression diffuse-type gastric cancer yasushi sasaki dna methylation appears aberrant dna methylation check access instant access full article pdf epigenetic analysis identifies related subjects repetitive dna elements dna methyltransferase stimulates privacy choices/manage cookies silences gene expression unbiased methylation profiling human breast cancer estrogen receptor expression cancer research institute tumor suppressor gene constitutive wnt signaling dna methylation hearing impairment gene human breast cancers author information authors primary breast cancers mcf7 cells confirmed human cancer cells article fujikane e-cadherin expression adenovirus-mediated transfer human bladder cancer human gene fkbp6 treating mcf7 cells human gastrointestinal tumors early epigenetic event european economic area

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         headline:Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
         description:Breast cancer arises through the accumulation of multiple genetic alterations and epigenetic changes such as methylation, which silences gene expression in a variety of cancers. In the present study, we applied genomic screening to identify genes upregulated by the demethylating agent 5-aza-2′-deoxycytidine (DAC) in a human breast cancer cell line (MCF7). We identified 288 genes upregulated and 29 genes downregulated more than fivefold after treatment with DAC, and gene ontology analyses revealed the genes to be involved in immune responses, apoptosis, and cell differentiation. In addition, real-time PCR analysis of ten genes silenced in MCF7 cells confirmed that they are upregulated by DAC, while bisulfite-pyrosequencing analysis confirmed that nine of those genes were silenced by methylation. We also found that treating MCF7 cells with DAC restored induction of DFNA5 by p53, as well as by two other p53 family genes, p63γ and p73β. Introduction of NTN4 into MCF7 cells suppressed cell growth, indicating that NTN4 has tumor suppressive activity. In primary breast cancers, we detected cancer-specific methylation of NTN4, PGP9.5, and DKK3, suggesting that methylation of these genes could be useful markers for diagnosis of breast cancer. Thus, DNA methylation appears to be a common event in breast cancer, and the genes silenced by methylation could be useful targets for both diagnosis and therapy.
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      name:Masami Ashida
      affiliation:
            name:Sapporo Medical University
            address:
               name:Department of Biochemistry, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Mutsumi Ohe-Toyota
      affiliation:
            name:Sapporo Medical University
            address:
               name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Masahiro Kai
      affiliation:
            name:Sapporo Medical University
            address:
               name:Department of Biochemistry, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Toshihiko Nishidate
      affiliation:
            name:Sapporo Medical University
            address:
               name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Yasushi Sasaki
      affiliation:
            name:Sapporo Medical University
            address:
               name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Tousei Ohmura
      affiliation:
            name:Sapporo Medical University
            address:
               name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Koichi Hirata
      affiliation:
            name:Sapporo Medical University
            address:
               name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
      name:Takashi Tokino
      affiliation:
            name:Sapporo Medical University
            address:
               name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
      name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
      name:Department of Biochemistry, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
      name:Department of Public Health, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
      name:Department of Biochemistry, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:Department of Biochemistry, Sapporo Medical University, Sapporo, Japan
      name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
      name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
      name:First Department of Surgery, Sapporo Medical University, Sapporo, Japan
      name:Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University, Sapporo, Japan
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