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         headline:Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses’ Health Study
         description:Repressive histone tail modifications have been associated with molecular breast cancer subtypes. We investigated whether histone 3 lysine 9 trimethylation (H3K9me3) and histone 3 lysine 27 trimethylation (H3K27me3) were associated with tumor features and subtypes while adjusting for prospectively collected reproductive and lifestyle breast cancer risk factors. We have tissue microarray data with immunohistochemical marker information on 804 incident cases of invasive breast cancer diagnosed from 1976–2000 in the Nurses’ Health Study. Tissue microarray sections were stained for global H3K9me3 and H3K27me3, and scored into four categories. Multivariate odds ratios (OR) and 95 % confidence intervals (CI) were calculated using logistic regression models for tumor features and subtypes, adjusting for breast cancer risk factors. While there were no significant associations between H3K9me3 and tumor features, H3K27me3 was significantly associated with lower grade tumors compared to high grade tumors in the multivariate model (OR = 1.95, 95 % CI 1.35–2.81, p = 0.0004). H3K27me3 was suggestively associated with estrogen receptor-positive (ER+) tumors (OR = 1.47, 95 % CI 0.97–2.23, p = 0.07). In subtype analyses, H3K27me3 was positively associated with the luminal A subtype compared to all other subtypes (OR = 1.42, 95 % CI 1.14–1.77, p = 0.002), and was inversely associated with HER2-type (OR = 0.58, 95 % CI 0.37–0.91, p = 0.02) and basal-like breast cancer (OR = 0.52, 95 % CI 0.36–0.76, p = 0.0006). In the largest immunohistochemical examination of H3K9me3 and H3K27me3 in breast cancer, we found that H3K27me3 positivity, but not H3K9me3, was associated with lower grade tumors and the luminal A subtype after adjusting for reproductive and lifestyle breast cancer risk factors.
         datePublished:2014-09-16T00:00:00Z
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      headline:Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses’ Health Study
      description:Repressive histone tail modifications have been associated with molecular breast cancer subtypes. We investigated whether histone 3 lysine 9 trimethylation (H3K9me3) and histone 3 lysine 27 trimethylation (H3K27me3) were associated with tumor features and subtypes while adjusting for prospectively collected reproductive and lifestyle breast cancer risk factors. We have tissue microarray data with immunohistochemical marker information on 804 incident cases of invasive breast cancer diagnosed from 1976–2000 in the Nurses’ Health Study. Tissue microarray sections were stained for global H3K9me3 and H3K27me3, and scored into four categories. Multivariate odds ratios (OR) and 95 % confidence intervals (CI) were calculated using logistic regression models for tumor features and subtypes, adjusting for breast cancer risk factors. While there were no significant associations between H3K9me3 and tumor features, H3K27me3 was significantly associated with lower grade tumors compared to high grade tumors in the multivariate model (OR = 1.95, 95 % CI 1.35–2.81, p = 0.0004). H3K27me3 was suggestively associated with estrogen receptor-positive (ER+) tumors (OR = 1.47, 95 % CI 0.97–2.23, p = 0.07). In subtype analyses, H3K27me3 was positively associated with the luminal A subtype compared to all other subtypes (OR = 1.42, 95 % CI 1.14–1.77, p = 0.002), and was inversely associated with HER2-type (OR = 0.58, 95 % CI 0.37–0.91, p = 0.02) and basal-like breast cancer (OR = 0.52, 95 % CI 0.36–0.76, p = 0.0006). In the largest immunohistochemical examination of H3K9me3 and H3K27me3 in breast cancer, we found that H3K27me3 positivity, but not H3K9me3, was associated with lower grade tumors and the luminal A subtype after adjusting for reproductive and lifestyle breast cancer risk factors.
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         Histone methylation
         Breast cancer
         Subtype
         Risk factor
         Oncology
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• How much income does https://doi.org/10.1002%2Fijc.23184 have?
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• How much does http://scholar.google.com/scholar_lookup?&title=Alcohol%20intake%20and%20risk%20of%20breast%20cancer%20defined%20by%20estrogen%20and%20progesterone%20receptor%20status%E2%80%94a%20meta-analysis%20of%20epidemiological%20studies&journal=Int%20J%20Cancer&doi=10.1002%2Fijc.23184&volume=122&issue=8&pages=1832-1841&publication_year=2008&author=Suzuki%2CR&author=Orsini%2CN&author=Mignone%2CL&author=Saji%2CS&author=Wolk%2CA pull in monthly?
• https://doi.org/10.1007/s10549-011-1702-0 income
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• Earnings of https://doi.org/10.1200%2FJCO.2002.09.023
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11981002?
• How much income does http://scholar.google.com/scholar_lookup?&title=The%20pathology%20of%20familial%20breast%20cancer%3A%20predictive%20value%20of%20immunohistochemical%20markers%20estrogen%20receptor%2C%20progesterone%20receptor%2C%20HER-2%2C%20and%20p53%20in%20patients%20with%20mutations%20in%20BRCA1%20and%20BRCA2&journal=J%20Clin%20Oncol&doi=10.1200%2FJCO.2002.09.023&volume=20&issue=9&pages=2310-2318&publication_year=2002&author=Lakhani%2CSR&author=Vijver%2CMJ&author=Jacquemier%2CJ&author=Anderson%2CTJ&author=Osin%2CPP&author=McGuffog%2CL&author=Easton%2CDF have?
• How profitable is https://doi.org/10.1093%2Fjnci%2Fdjg050?
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• How much profit does https://doi.org/10.1038/nature11154 generate?
• https://doi.org/10.1038%2Fnature11154's financial summary
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• How much does http://scholar.google.com/scholar_lookup?&title=Sequence%20analysis%20of%20mutations%20and%20translocations%20across%20breast%20cancer%20subtypes&journal=Nature&doi=10.1038%2Fnature11154&volume=486&issue=7403&pages=405-409&publication_year=2012&author=Banerji%2CS&author=Cibulskis%2CK&author=Rangel-Escareno%2CC&author=Brown%2CKK&author=Carter%2CSL&author=Frederick%2CAM&author=Lawrence%2CMS&author=Sivachenko%2CAY&author=Sougnez%2CC&author=Zou%2CL&author=Cortes%2CML&author=Fernandez-Lopez%2CJC&author=Peng%2CS&author=Ardlie%2CKG&author=Auclair%2CD&author=Bautista-Pina%2CV&author=Duke%2CF&author=Francis%2CJ&author=Jung%2CJ&author=Maffuz-Aziz%2CA&author=Onofrio%2CRC&author=Parkin%2CM&author=Pho%2CNH&author=Quintanar-Jurado%2CV&author=Ramos%2CAH&author=Rebollar-Vega%2CR&author=Rodriguez-Cuevas%2CS&author=Romero-Cordoba%2CSL&author=Schumacher%2CSE&author=Stransky%2CN&author=Thompson%2CKM&author=Uribe-Figueroa%2CL&author=Baselga%2CJ&author=Beroukhim%2CR&author=Polyak%2CK&author=Sgroi%2CDC&author=Richardson%2CAL&author=Jimenez-Sanchez%2CG&author=Lander%2CES&author=Gabriel%2CSB&author=Garraway%2CLA&author=Golub%2CTR&author=Melendez-Zajgla%2CJ&author=Toker%2CA&author=Getz%2CG&author=Hidalgo-Miranda%2CA&author=Meyerson%2CM pull in?
• Earnings of https://doi.org/10.1038/nature10983
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• How much does https://doi.org/10.1038/nature11143 earn?
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• See how much https://doi.org/10.1038/nature11412 makes per month
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• What's the income of https://doi.org/10.1038/nature10933?
• What's the total monthly financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22495314?
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• https://doi.org/10.1371%2Fjournal.pgen.1000054's financial summary
• How much income does http://scholar.google.com/scholar_lookup?&title=Heterogeneity%20of%20breast%20cancer%20associations%20with%20five%20susceptibility%20loci%20by%20clinical%20and%20pathological%20characteristics&journal=PLoS%20Genet&doi=10.1371%2Fjournal.pgen.1000054&volume=4&issue=4&publication_year=2008&author=Garcia-Closas%2CM&author=Hall%2CP&author=Nevanlinna%2CH&author=Pooley%2CK&author=Morrison%2CJ&author=Richesson%2CDA&author=Bojesen%2CSE&author=Nordestgaard%2CBG&author=Axelsson%2CCK&author=Arias%2CJI&author=Milne%2CRL&author=Ribas%2CG&author=Gonzalez-Neira%2CA&author=Benitez%2CJ&author=Zamora%2CP&author=Brauch%2CH&author=Justenhoven%2CC&author=Hamann%2CU&author=Ko%2CYD&author=Bruening%2CT&author=Haas%2CS&author=Dork%2CT&author=Schurmann%2CP&author=Hillemanns%2CP&author=Bogdanova%2CN&author=Bremer%2CM&author=Karstens%2CJH&author=Fagerholm%2CR&author=Aaltonen%2CK&author=Aittomaki%2CK&author=Smitten%2CK&author=Blomqvist%2CC&author=Mannermaa%2CA&author=Uusitupa%2CM&author=Eskelinen%2CM&author=Tengstrom%2CM&author=Kosma%2CVM&author=Kataja%2CV&author=Chenevix-Trench%2CG&author=Spurdle%2CAB&author=Beesley%2CJ&author=Chen%2CX&author=Devilee%2CP&author=Asperen%2CCJ&author=Jacobi%2CCE&author=Tollenaar%2CRA&author=Huijts%2CPE&author=Klijn%2CJG&author=Chang-Claude%2CJ&author=Kropp%2CS&author=Slanger%2CT&author=Flesch-Janys%2CD&author=Mutschelknauss%2CE&author=Salazar%2CR&author=Wang-Gohrke%2CS&author=Couch%2CF&author=Goode%2CEL&author=Olson%2CJE&author=Vachon%2CC&author=Fredericksen%2CZS&author=Giles%2CGG&author=Baglietto%2CL&author=Severi%2CG&author=Hopper%2CJL&author=English%2CDR&author=Southey%2CMC&author=Haiman%2CCA&author=Henderson%2CBE&author=Kolonel%2CLN&author=Marchand%2CL&author=Stram%2CDO&author=Hunter%2CDJ&author=Hankinson%2CSE&author=Cox%2CDG&author=Tamimi%2CR&author=Kraft%2CP&author=Sherman%2CME&author=Chanock%2CSJ&author=Lissowska%2CJ&author=Brinton%2CLA&author=Peplonska%2CB&author=Hooning%2CMJ&author=Meijers-Heijboer%2CH&author=Collee%2CJM&author=Ouweland%2CA&author=Uitterlinden%2CAG&author=Liu%2CJ&author=Lin%2CLY&author=Yuqing%2CL&author=Humphreys%2CK&author=Czene%2CK&author=Cox%2CA&author=Balasubramanian%2CSP&author=Cross%2CSS&author=Reed%2CMW&author=Blows%2CF&author=Driver%2CK&author=Dunning%2CA&author=Tyrer%2CJ&author=Ponder%2CBA&author=Sangrajrang%2CS&author=Brennan%2CP&author=McKay%2CJ&author=Odefrey%2CF&author=Gabrieau%2CV&author=Sigurdson%2CA&author=Doody%2CM&author=Struewing%2CJP&author=Alexander%2CB&author=Easton%2CDF&author=Pharoah%2CPD have?
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