We are analyzing https://link.springer.com/article/10.1007/s12282-009-0176-y.

Title:
Breast cancer stem cells | Breast Cancer
Description:
Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44-positive (CD24−/CD44+) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.
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Keywords {🔍}

cells, cancer, stem, article, pubmed, google, scholar, cas, breast, cell, research, nat, human, mammary, bcscs, rev, privacy, cookies, content, access, nature, publish, search, data, information, log, journal, kai, arima, kamiya, hideyuki, saya, emerging, properties, targeting, marker, discover, dick, hematopoietic, med, visvader, lindeman, mouse, res, side, population, tumor, usa, niche, download,

Topics {✒️}

month download article/chapter toshio kamiya & hideyuki saya cancer stem cells cd24-negative/cd44-positive breast cancer cells leukemia stem cells glioblastoma stem cells oxidative stress-responsive genes resist anti-cancer therapy cell stem cell targeting cancer cells including breast cancer stem cell rev breast cancer tissues early breast cancer stem cells human tumor cells advanced medical research full article pdf cancer research related subjects privacy choices/manage cookies breast cancer breast cancer 17 nat rev cancer devising innovative therapies distinct “side population” cell surface markers primitive hematopoietic cell mol biol cell epithelial-mesenchymal transitions dick je hematopoietic cells article kai express higher levels hideyuki saya european economic area mammary tumorigenesis goodell ma charafe-jauffret distinct molecular signature ros-mediated mechanisms n-cadherin expression basal cells conditions privacy policy asselin-labat m article log bcrp1 gene expression confers relative protection poor clinical outcome

Questions {❓}

Trachootham D, Alexandre J, Huang P: Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Schema {🗺️}

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