We are analyzing https://link.springer.com/article/10.1186/bcr2567.

Title:
At last, a predictive and prognostic marker for radiotherapy? | Breast Cancer Research
Description:
Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers.
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Keywords {🔍}

hjurp, breast, cancer, radiotherapy, article, pubmed, prognostic, google, scholar, sensitivity, radiation, cell, predictive, protein, cenpa, cas, data, marker, repair, thompson, randomised, trials, survival, high, cells, privacy, cookies, research, dewar, proliferation, dna, markers, early, information, publish, search, coates, alastair, holliday, junction, levels, prognosis, increased, association, clinical, tissues, biomarkers, response, patients, treatment,

Topics {✒️}

dna damage repair tumor markers cell-cycle-dependent maintenance repair ongoing damage references hu privacy choices/manage cookies early breast cancer breast cancer associate breast cancer res categorise breast cancers article coates conventional prognostic features european economic area generally radiosensitive compared strong pretreatment indicator sole tissue resource neoadjuvant concurrent paclitaxel independent prognostic variable independent prognostic impact conditions privacy policy poor prognostic features clin cancer res centromere-specific assembly show enhanced repair randomised controlled trials cell lines correlated cell line studies cell cycle regulated article number 106 accepting optional cookies partial breast radiation authors declare barrett-lee pj disease-free survival accurate chromosome segregation article cite including er-negative dna repair chemo/radiotherapy outcome [11] john dewar & alastair simply reflect proliferation journal finder publish author correspondence show increased sensitivity hjurp knockdown cells poor prognosis her2 receptor expression high tumour hjurp breast cancer high hjurp mrna

Questions {❓}

At last, a predictive and prognostic marker for radiotherapy?
At last, a predictive and prognostic marker for radiotherapy?
In HJURP, do we at last have a predictive and prognostic marker for who should (or should not) have radiotherapy?
Is HJURP the driving force for radiation sensitivity, or does it reflect another aspect of tumour pathobiology?

Schema {🗺️}

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         headline:At last, a predictive and prognostic marker for radiotherapy?
         description:Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers.
         datePublished:2010-05-11T00:00:00Z
         dateModified:2010-05-11T00:00:00Z
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      headline:At last, a predictive and prognostic marker for radiotherapy?
      description:Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers.
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         Surgical Oncology
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      name:Dundee Cancer Centre, Ninewells Hospital and Medical School and University of Dundee, Dundee, UK
      name:Dundee Cancer Centre, Ninewells Hospital and Medical School and University of Dundee, Dundee, UK
      name:Department of Surgical Oncology, MD Anderson Cancer Center, Houston, USA

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