We are analyzing https://link.springer.com/article/10.1007/s10555-023-10146-7.

Title:
Epigenetic regulation of breast cancer metastasis | Cancer and Metastasis Reviews
Description:
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully understood. However, emerging body of evidence indicates that in addition to genetic changes, epigenetic reprogramming of cancer cells and the metastatic niche are paramount toward successful metastasis. Here, we review and discuss the latest knowledge about the salient attributes of metastasis and epigenetic regulation in breast cancer and crucial research domains that need further investigation.
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Keywords {🔍}

pubmed, cancer, scholar, google, article, cas, breast, central, metastasis, cell, cells, research, journal, metastatic, tumor, nature, epigenetic, molecular, methylation, histone, stem, dna, oncology, clinical, expression, gene, human, progression, biology, promotes, transition, signaling, therapy, bone, regulation, reports, epithelialmesenchymal, cancers, triplenegative, primary, patients, reviews, niche, epigenetics, treatment, metastases, tumors, communications, mdig, thakur,

Topics {✒️}

calcineurin-nfat-angiopoietin-2 signaling axis letrozole-resistant mcf-7ca xenografts activating cdh1/skp2/p27kip1 pathway month download article/chapter cenp-a-histone h4 heterodimer snail-mediated e-cadherin repression tgf-β1-induced epithelial wnt/β-catenin signaling wnt/beta-catenin pathway c-myc-p300 complex silica-induced pulmonary fibrosis triple-negative breast cancer hypoxia-induced lysyl oxidase src-dependent survival signals a-enriched gene transcripts replication-dependent histone isoforms e-cadherin promotes metastasis breast-cancer stem cells functional molecules-based approaches nicotinamide n-methyltransferase sustains circulating cell-free dna pre-metastatic niche formation large single-centre analysis e-cadherin pd-l1 promote epithelial-mesenchymal transition cytosine-phosphate-guanine adam12 tumor-derived aberrant methylation lsd1/nurd suppresses angiogenesis emt-inducing transcription factors metastatic prostate cancer network finds microenvironment prospective case-cohort analysis epithelial-mesenchymal transition triggers src/fak signaling activation-induced cell death microrna regulatory networks full article pdf prmt5-wdr77/crl4b complex ezh2-mediated epigenetic silencing er+ breast cancer promotes metastatic colonization paracrine wnt signaling metastasis-initiating cells hybrid epithelial/mesenchymal state receptor 2-mediated activation metastatic colonization requires tissue factor induced hypoxic tumor microenvironment prmt7 induces epithelial breast cancer identifies

Questions {❓}

At last, a predictive and prognostic marker for radiotherapy?
EMT and MET: Necessary or permissive for metastasis?
Intra-tumour heterogeneity: A looking glass for cancer?
Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?
The pre-metastatic niche: Is metastasis random?

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