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We are analyzing https://www.nature.com/articles/s41580-018-0001-6.

Title:
The coming of age of chaperone-mediated autophagy | Nature Reviews Molecular Cell Biology
Description:
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective β€” a concept that is now well accepted for other forms of autophagy. Lysosomes can degrade cellular cytosol in a nonspecific manner but can also discriminate what to target for degradation with the involvement of a degradation tag, a chaperone and a sophisticated mechanism to make the selected proteins cross the lysosomal membrane through a dedicated translocation complex. Recent studies modulating CMA activity in vivo using transgenic mouse models have demonstrated that selectivity confers on CMA the ability to participate in the regulation of multiple cellular functions. Timely degradation of specific cellular proteins by CMA modulates, for example, glucose and lipid metabolism, DNA repair, cellular reprograming and the cellular response to stress. These findings expand the physiological relevance of CMA beyond its originally identified role in protein quality control and reveal that CMA failure with age may aggravate diseases, such as ageing-associated neurodegeneration and cancer. The selective degradation of cellular components via chaperone-mediated autophagy (CMA) functions to regulate a wide range of cellular processes, from metabolism to DNA repair and cellular reprogramming. Recent in vivo studies have enabled to dissect key roles of CMA in ageing and ageing-associated disorders such as cancer and neurodegeneration.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Education
  • Telecommunications
  • Science

Content Management System {πŸ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of nature.com audience?

πŸ™οΈ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 50,449,386 visitors per month in the current month.

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How Does Nature.com Make Money? {πŸ’Έ}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {πŸ’°}


Display Ads {🎯}

$640,000 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $423,817 to $1,165,496.

Keywords {πŸ”}

pubmed, article, google, scholar, cas, autophagy, chaperonemediated, central, cell, degradation, lysosomal, cuervo, biol, protein, proteins, nature, mol, cma, dice, membrane, chem, selective, disease, kaushik, lipid, cancer, nat, sci, receptor, alphasynuclein, intracellular, access, cells, content, molecular, cellular, liver, promotes, lampa, lysosomes, response, death, growth, pathway, survival, res, chaperone, metabolism, role, aging,

Topics {βœ’οΈ}

nature portfolio journals nature portfolio permissions reprints privacy policy advertising ana maria cuervo social media regional deficiencies chaperone-mediated autophagy-essential gene chaperone-mediated autophagy-dependent degradation nature+ nature 458 nature development track chaperone-mediated autophagy harnessing chaperone-mediated autophagy boosting chaperone-mediated autophagy monitor chaperone-mediated autophagy deregulated chaperone-mediated autophagy chaperone-mediated autophagy depends chaperone-mediated autophagy markers chaperone-mediated autophagy compensates suppress oxaliplatin-induced apoptosis chaperone-mediated autophagy regulates regulates chaperone-mediated autophagy molecular biology deficient chaperone-mediated autophagy abnormal chaperone-mediated autophagy chaperone-mediated autophagy components wild type alpha-synuclein chaperone-mediated autophagy leads deubiquitinating enzyme uch-l1 inhibit irradiation-triggered apoptosis misfolded n-cor protein promote cell-cycle progression molecular chaperone complex chaperone-assisted selective autophagy hypoxia-inducible factor 1alpha hypoxia-inducible factor 1Ξ± lysosomal-mediated autophagic genes central nervous system springerlink instant access single-span membrane proteins susmita kaushik chaperone-mediated autophagy chaperone mediated autophagy permissions article kaushik hsc70-mediated lysosomal degradation vacuolar-protein-sorting proteins

Questions {❓}

  • To be or not to be?
  • VEXAS, Chediak–Higashi syndrome and Danon disease: myeloid cell endo-lysosomal pathway dysfunction as a common denominator?

Schema {πŸ—ΊοΈ}

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