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Keywords {🔍}

αsyn, cma, protein, lysosomes, doi, lysosomal, figure, degradation, dopamine, cells, pubmed, google, scholar, effect, membrane, neurons, forms, mutant, daαsyn, cytosolic, binding, oligomers, isolated, percentage, intracellular, proteins, association, autophagy, cultures, wildtype, observed, pmc, gapdh, previously, article, form, incubation, calculated, unmodified, alphasynuclein, shown, inhibition, activity, modifications, uptake, bound, substrates, blockage, dopaminergic, panel,

Topics {✒️}

soluble wild-type α-syn oxidized wild-type α-syn wild-type purified α-syn virus-free fresh medium wild-type alpha-synuclein dac–α-syn closely resembled α-syn–null mice treated da–α-syn oligomers appeared wild-type α-syn da–α-syn blocks cma exogenously added da–α-syn da–α-syn inside cells alpha-synuclein null mice da–α-syn inhibited cma dopamine-insensitive mutant α-syn α-syn moderately reduced wild-type vm neurons dopamine-alpha-synuclein adduct high-performance liquid chromatography [pubmed] [google scholar] pmc beta search α-syn–knockout mice lysosomal-bound oxidized α-syn α-syn–null mice β-sheet rich oligomer dopaminochrome-mediated conformational alterations increased alpha-synuclein expression chaperone-mediated autophagy depends dopamine-induced noncovalent alterations chromaffin-dense core vesicles pmc copyright notice coomassie blue–stained protein sh-sy5y cells covalently cross-linked dimers irreversibly cross-linked dimers nitrated α-syn species intracellular da–α-syn α-syn displayed resistance cytosolic da–α-syn s129e mutant α-syn initial acid-precipitable radioactivity dopamine-reacted α-syn purified da–α-syn dopamine precursor l-dopa wild-type protein dopamine-modified α-syn a-synuclein tyrosine nitration smaller α-syn oligomers dopaminochrome-modified α-syn sds-resistant soluble oligomers

Questions {❓}

• Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson’s disease?

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