Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025268, but it redirected us to https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025268. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is doi.org built with?


Doi.org utilizes WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be cashing in, but we can't detect the method they're using.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

ncor, cells, nsclc, loss, cell, cancer, lung, article, misfolded, view, fig, google, scholar, protein, determined, level, assay, hsc, human, flagtagged, growth, cma, degradation, role, stress, incubated, lysosomal, plos, antibody, autophagy, survival, panel, tumor, proteins, linked, function, normal, apl, primary, derived, misfolding, usa, mediated, suggesting, tissue, performed, dms, extract, saec, treated,

Topics {✒️}

cookies plos plos fusion onco-protein eml4–alk nicotine-induced n-cor loss results post-transcriptional loss stressed endoplasmic reticulum recombinant flag-tagged n-cor small-cell lung cancer small-cell lung cancer open-access article distributed flag-tagged n-cor plasmid including pi3k/akt/mtor pathway flag-tagged n-cor protein wild type alpha-synuclein flag-tagged n-cor incubated endoplasmic reticulum [7] endoplasmic reticulum aberrant post-translational modification n-cor cleaving activity contributed reagents/materials/analysis tools human tumors full length n-cor mis-folded nuclear receptor n-cor expression plasmid cleaved n-cor fragment flag-tagged n-cor original author hsc70-cargo complex pi3k/akt/mtor pathway methods cell lines n-cor peptide sequence n-cor-mediated repression n-cor cleavage assay solid tumors intact n-cor protein singapore-institutional review board n-cor protein stabilized rhodamine-conjugated secondary antibodies heat labile protease misfolded n-cor protein exhibited n-cor loss n-cor-flag incubated misfolded n-cor presented normal n-cor conformation supporting information s1 misfolded-conformation dependent loss nuclear n-cor found protease-depleted cytosolic extract effective anti-lamp2a sirna lung cancer tissue

Social Networks {👍}(3)

External Links {🔗}(160)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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