
NCBI . NLM . NIH . GOV {
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Title[redir]:
Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation - PMC
Description:
The activity of chaperone-mediated autophagy (CMA), a catabolic pathway for selective degradation of cytosolic proteins in lysosomes, decreases with age, but the consequences of this functional decline in vivo remain unknown. In this work, we have ...
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Keywords {🔍}
mice, fig, lako, cma, doi, liver, ctr, enzymes, levels, degradation, lysosomal, lipid, livers, higher, metabolism, pubmed, google, scholar, proteins, lysosomes, glycolytic, cuervo, glucose, analysis, metabolic, hepatic, reduced, pmc, values, gapdh, fed, free, activity, increase, autophagy, article, cytosolic, starved, content, lampa, protein, cells, substrates, chaperonemediated, dice, starvation, differences, found, increased, carbohydrate,
Topics {✒️}
free fatty acids high-fat diet chaperone-mediated autophagy depends alb-cre mice glyceraldehyde 3-phosphate dehydrogenase glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde-3- phosphate dehydrogenase regular chow diet nih/nia t32-gm007288 respiratory exchange ratio pmc beta search alb-cre proportional male/female ratios ketone body-mediated upregulation increased energy expenditure chaperone-mediated autophagy chaperone-substrate complex reaches bonferroni post-hoc test cell metab summary long chain acetyl-coenzyme fatty acid biosynthesis periodic acid-schiff stain albumin-cre mice acetyl-coa production resulting albumin-cre-l2af/ floxed lamp-2a allele zoxazolamine-induced paralysis test excessive acetyl-coa generated glycerol-3-phosphate dehydrogenase publisher site pdf serum free media glycogen synthetase bovine serum albumin cma-resistant mutant gapdh myc-tagged wild-type energy expenditure dehydrogenase long chain mitochondria-resident tca enzymes cma-deficient livers exhibit lamp-2a-dependent manner body energy homeostasis increased gs activation liver-specific l2ako mice supplementary materials included albumin-cre tca cycle-related enzymes ratio autophagosome/autophagolysosome displayed lower rates reduced fat mass maximal respiratory capacity
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