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We began analyzing https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1214777, but it redirected us to https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1214777. The analysis below is for the second page.

Title[redir]:
Full article: Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
Description:
Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein α), a protein strongly implicated in Parkinson disease (PD) pathogenesi...

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Keywords {🔍}

open, lampa, neurons, snca, animals, fig, science, autophagy, nigral, cma, gfp, source, windowgoogle, scholar, chaperonemediated, cell, pmid, windowpubmed, windowweb, levels, dopaminergic, protein, shown, loss, disease, lysosomal, accumulation, postinjection, linjected, rat, compared, panel, analysis, puncta, downregulation, lysosomes, lamp, contralateral, research, significant, journal, degradation, time, scrinjected, brain, control, quantification, rats, scr, row,

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pa2sgw-synapsin-gfp-u6-sirna raav vector lamp-1/lamp-2 double-deficient fibroblasts snca-conjugated gold/silver particles social care medicine supplemental material kaup_a_1214777_supplementary_material raav-shlamp2a-transduced nigral neurons sciences behavioral tests l2 shrna-raav-injected rats boosting chaperone-mediated autophagy google scholar reprints enzo life sciences di-n-butyl phthalate deficient chaperone-mediated autophagy chaperone-mediated autophagy markers chaperone-mediated autophagy source margarita chrysanthou-piterouresearch unit conventional photon-multiplier tube high-performance liquid chromatography double-positive cells showed general raav-vector design wild type α-synuclein high-power immunofluorescence images pa2sgw-synapsin-gfp vector lamp-2-deficient mice source display full size google scholar alvarez-erviti 150 mm nacl [lach-ner nanogold anti-mouse igg raav-shrna-injected animals gfp-tagged raav-shrnas calcium-phosphate precipitation method snca/syn-1/α-synuclein represent higher-grade aggregates oxidized/nitrated recombinant snca amphetamine-induced rotations hspa8/hsc70citation21 protein levels cytosolic chaperone hspa8/hsc70 scr-shrna-injected rats gfp-shrna-transduced neurons academic press aav-mediated shrna expression lamp2a shrna-treated animals shrna-lamp2a treated animals pre-embedding immunohistochemical procedures snca levels/aggregation selectively l2 raav-injected animals references cuervo chaperone-mediated autophagy lamp2a-shrna injected animals puncta/gfp+ cell profile

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      articleSection:Translational Research Paper
      name:Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
      headline:Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
      abstract:Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein Î±), a protein strongly implicated in Parkinson disease (PD) pathogenesis. However, the physiological role of CMA and the consequences of CMA failure in the living brain remain elusive. Here we show that CMA inhibition in the adult rat substantia nigra via adeno-associated virus-mediated delivery of short hairpin RNAs targeting the LAMP2A receptor, involved in CMA&#039;s rate limiting step, was accompanied by intracellular accumulation of SNCA-positive puncta, which were also positive for UBIQUITIN, and in accumulation of autophagic vacuoles within LAMP2A-deficient nigral neurons. Strikingly, LAMP2A downregulation resulted in progressive loss of nigral dopaminergic neurons, severe reduction in striatal dopamine levels/terminals, increased astro- and microgliosis and relevant motor deficits. Thus, this study highlights for the first time the importance of the CMA pathway in the dopaminergic system and suggests that CMA impairment may underlie PD pathogenesis.
      description:Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein Î±), a protein strongly implicated in Parkinson disease (PD) pathogenesis. However, the physiological role of CMA and the consequences of CMA failure in the living brain remain elusive. Here we show that CMA inhibition in the adult rat substantia nigra via adeno-associated virus-mediated delivery of short hairpin RNAs targeting the LAMP2A receptor, involved in CMA&#039;s rate limiting step, was accompanied by intracellular accumulation of SNCA-positive puncta, which were also positive for UBIQUITIN, and in accumulation of autophagic vacuoles within LAMP2A-deficient nigral neurons. Strikingly, LAMP2A downregulation resulted in progressive loss of nigral dopaminergic neurons, severe reduction in striatal dopamine levels/terminals, increased astro- and microgliosis and relevant motor deficits. Thus, this study highlights for the first time the importance of the CMA pathway in the dopaminergic system and suggests that CMA impairment may underlie PD pathogenesis.
      author:
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            type:Person
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            type:Person
            name:Oeystein Roed Brekk
            type:Person
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            name:Margarita Chrysanthou-Piterou
            type:Person
            name:Ismini Kloukina
            type:Person
            name:Maria Xilouri
            type:Person
            name:Maria Xilouri
            type:Person
            name:Maria Xilouri
            type:Person
            name:Maria Xilouri
            type:Person
            name:Maria Xilouri
            type:Person
            name:Maria Xilouri
            type:Person
            name:Leonidas Stefanis
      keywords:chaperone-mediated autophagy, LAMP2A, lysosomes, Parkinson disease, synuclein Î±
      pageStart:2230
      pageEnd:2247
      datePublished:2016-11-01
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