NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC4400843/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC4400843/. The analysis below is for the second page.
Title[redir]:
Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage - PMC
Description:
Chaperone-mediated autophagy (CMA) is activate in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality ...
Title[redir]:
Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage - PMC
Description:
Chaperone-mediated autophagy (CMA) is activate in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality ...
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Keywords {🔍}
cells, chk, fig, cma, dna, etoposide, doi, levels, nuclear, degradation, damage, cell, proteins, experiments, repair, supplementary, treatment, pubmed, google, scholar, lysosomal, protein, ctr, treated, autophagy, pmc, mrn, higher, independent, shown, pchk, lysosomes, immunoblot, article, control, γhax, hsc, knockdown, cellular, activity, untreated, free, blockage, complex, genotoxic, cycle, observed, atr, response, mouse,
Topics {✒️}
gfp-chk1-aa remained unchanged [pubmed] [google scholar] γ-irradation-induced dna damage high-resolution ccd camera pmc beta search 50mm tris-hcl ph7 bonferroni post-hoc test 5mm tris-hcl ph7 mutation research/genetic toxicology chaperone-mediated autophagy depends track chaperone-mediated autophagy monitor chaperone-mediated autophagy photoactivable kferq-dendra reporter chk1-atr regulatory circuit light mitochondrial-lysosomal fraction hrp-conjugated secondary antibodies specific cma-targeting motif double-strand breaks cma-deficient cells make cells expressing wild-type mcherry-gfp-lc3 reporter cma-active lysosomes confirming cma-specific fluorescent substrate abnormal atr-dependent phosphorylation wild-type untreated animals chk1 cma-targeting motif hsc70-bound chk1 increased sds–page gels bovine serum albumin sucrose density centrifugation cell cycle checkpoints license information pmcid 50mm tris-hcl dna damage checkpoint post-translational modifications increases cell death etoposide-induced dna dsbs wild-type untreated elicit higher susceptibility cell cycle distribution cell cycle arrest 5mm na2hpo4 ph7 deficient dna repair reduced cell survival chk1 protein susceptible dna repair pathways trends biochem sci dna damage load nih/nigms t32gm007288 folin phenol reagent
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