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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10555-023-10136-9.

Title:
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review | Cancer and Metastasis Reviews
Description:
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target genes and dysregulated pathways in tumor invasion and migration. Therefore, targeting HIF-1 pathway and cross-talked mediators seems to be a novel strategy in cancer prevention and treatment. In recent decades, tremendous efforts have been made to develop multi-targeted therapies to modulate several dysregulated pathways in cancer angiogenesis, invasion, and metastasis. In this line, natural compounds have shown a bright future in combating angiogenic and metastatic conditions. Among the natural secondary metabolites, we have evaluated the critical potential of phenolic compounds, terpenes/terpenoids, alkaloids, sulfur compounds, marine- and microbe-derived agents in the attenuation of HIF-1, and interconnected pathways in fighting tumor-associated angiogenesis and invasion. This is the first comprehensive review on natural constituents as potential regulators of HIF-1 and interconnected pathways against cancer angiogenesis and metastasis. This review aims to reshape the previous strategies in cancer prevention and treatment.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, google, scholar, cas, cancer, article, central, cells, inhibits, transition, journal, cell, wang, signaling, chen, zhang, liu, metastasis, growth, human, invasion, pathway, epithelialmesenchymal, molecular, breast, research, migration, angiogenesis, suppresses, lung, carcinoma, tumor, oncology, factor, kim, international, natural, reports, yang, lee, anticancer, effects, inhibition, pathways, medicine, proliferation, lin, pharmacology, epithelialtomesenchymal, targeting,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated igfbp3-akt/stat3/mapk-snail signalling pathway regulating mir-410–3p/hmgb1/nf-κb pathway nuclear factor kappa-light-chain-enhancer attenuating glut1/mt1-mmp/mmp2 pathway pi-3k/akt/nf-κb pathway akt/gsk-3β/snail signaling pathway spock1-snail/slug axis-mediated epithelial p38 mapk/gsk-3β/zeb1 pathway egfr-fak-akt/erk1/2-slug signaling pathway cthrc1-akt/erk-snail signaling pathway tgf-β/alk5/smad signaling pathway autophagy-dependent wnt/β-catenin signaling pi3k/akt-nf-κb-snail pathway ros/erk/slug/e-cadherin pathway pi3k/akt/nf-κb signaling pathway tgf-β1/smad signaling pathway il-6-jak1-stat3 feedback loop regulates lncrna-xist/mir-335 axis pi3k/akt/mtor signalling pathway tgf-β/smad signaling pathway tgf-β1/smad3 signaling pathway targeting axin2/e-cadherin axis nf-kappab-regulated gene products wnt/β-catenin signaling pathway tak1-mediated nf-kappab activation transforming growth factor-β1 sensitizes tnf-α-induced apoptosis tgf-β/smad2/3 signaling pathway pi3k/akt/mtor signaling pathway month download article/chapter nuclear factor-κb–dependent epithelial receptor/nuclear factor-κb pathways tgf-β1-mediated pi3k autophagy-dependent wnt/β-catenin hypoxia-inducible factor-1-dependent mechanisms tlr/nf-κb/nlrp signaling linc00668/mir-432-5p/emt axis blocking wnt/β-catenin signaling nf-κb-regulated gene products nf-κb-regulated gene expression hypoxia-inducible factor-1α induction transcription 3/zeb1/e-cadherin axis hypoxia-induced epithelial-mesenchymal transition radiation-induced epithelial-mesenchymal transition nf-κb/snail signaling pathway pi3k/akt/mtor signaling pathways akt/nf-κb signaling pathway pten-pi3k-akt signaling pathway inhibiting β-catenin-mediated angiogenesis

Schema {🗺️}

WebPage:
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         description:Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target genes and dysregulated pathways in tumor invasion and migration. Therefore, targeting HIF-1 pathway and cross-talked mediators seems to be a novel strategy in cancer prevention and treatment. In recent decades, tremendous efforts have been made to develop multi-targeted therapies to modulate several dysregulated pathways in cancer angiogenesis, invasion, and metastasis. In this line, natural compounds have shown a bright future in combating angiogenic and metastatic conditions. Among the natural secondary metabolites, we have evaluated the critical potential of phenolic compounds, terpenes/terpenoids, alkaloids, sulfur compounds, marine- and microbe-derived agents in the attenuation of HIF-1, and interconnected pathways in fighting tumor-associated angiogenesis and invasion. This is the first comprehensive review on natural constituents as potential regulators of HIF-1 and interconnected pathways against cancer angiogenesis and metastasis. This review aims to reshape the previous strategies in cancer prevention and treatment.
         datePublished:2023-10-04T00:00:00Z
         dateModified:2023-10-04T00:00:00Z
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            Hypoxia-inducible factor-1
            Angiogenesis
            Metastasis
            Natural agents
            Therapeutic targets
            Cancer Research
            Oncology
            Biomedicine
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      headline:Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
      description:Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target genes and dysregulated pathways in tumor invasion and migration. Therefore, targeting HIF-1 pathway and cross-talked mediators seems to be a novel strategy in cancer prevention and treatment. In recent decades, tremendous efforts have been made to develop multi-targeted therapies to modulate several dysregulated pathways in cancer angiogenesis, invasion, and metastasis. In this line, natural compounds have shown a bright future in combating angiogenic and metastatic conditions. Among the natural secondary metabolites, we have evaluated the critical potential of phenolic compounds, terpenes/terpenoids, alkaloids, sulfur compounds, marine- and microbe-derived agents in the attenuation of HIF-1, and interconnected pathways in fighting tumor-associated angiogenesis and invasion. This is the first comprehensive review on natural constituents as potential regulators of HIF-1 and interconnected pathways against cancer angiogenesis and metastasis. This review aims to reshape the previous strategies in cancer prevention and treatment.
      datePublished:2023-10-04T00:00:00Z
      dateModified:2023-10-04T00:00:00Z
      pageStart:501
      pageEnd:574
      sameAs:https://doi.org/10.1007/s10555-023-10136-9
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         Cancer
         Hypoxia-inducible factor-1
         Angiogenesis
         Metastasis
         Natural agents
         Therapeutic targets
         Cancer Research
         Oncology
         Biomedicine
         general
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                  address:
                     name:Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seyed Zachariah Moradi
            url:http://orcid.org/0000-0003-0579-3495
            affiliation:
                  name:Health Institute, Kermanshah University of Medical Sciences
                  address:
                     name:Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
                     type:PostalAddress
                  type:Organization
                  name:Health Technology Institute, Kermanshah University of Medical Sciences
                  address:
                     name:Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Farahnaz Faraji
            url:http://orcid.org/0000-0002-5476-3463
            affiliation:
                  name:Hamadan University of Medical Sciences
                  address:
                     name:Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leila Kooshki
            url:http://orcid.org/0000-0003-1071-1917
            affiliation:
                  name:Kermanshah University of Medical Sciences
                  address:
                     name:Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kassidy Webber
            url:http://orcid.org/0000-0002-9777-9342
            affiliation:
                  name:Lake Erie College of Osteopathic Medicine
                  address:
                     name:College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anupam Bishayee
            url:http://orcid.org/0000-0001-9159-960X
            affiliation:
                  name:Lake Erie College of Osteopathic Medicine
                  address:
                     name:College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA
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      affiliation:
            name:Health Institute, Kermanshah University of Medical Sciences
            address:
               name:Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
               type:PostalAddress
            type:Organization
      name:Seyed Zachariah Moradi
      url:http://orcid.org/0000-0003-0579-3495
      affiliation:
            name:Health Institute, Kermanshah University of Medical Sciences
            address:
               name:Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
               type:PostalAddress
            type:Organization
            name:Health Technology Institute, Kermanshah University of Medical Sciences
            address:
               name:Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
               type:PostalAddress
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      name:Farahnaz Faraji
      url:http://orcid.org/0000-0002-5476-3463
      affiliation:
            name:Hamadan University of Medical Sciences
            address:
               name:Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
               type:PostalAddress
            type:Organization
      name:Leila Kooshki
      url:http://orcid.org/0000-0003-1071-1917
      affiliation:
            name:Kermanshah University of Medical Sciences
            address:
               name:Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
               type:PostalAddress
            type:Organization
      name:Kassidy Webber
      url:http://orcid.org/0000-0002-9777-9342
      affiliation:
            name:Lake Erie College of Osteopathic Medicine
            address:
               name:College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA
               type:PostalAddress
            type:Organization
      name:Anupam Bishayee
      url:http://orcid.org/0000-0001-9159-960X
      affiliation:
            name:Lake Erie College of Osteopathic Medicine
            address:
               name:College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA
               type:PostalAddress
            type:Organization
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      name:Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
      name:Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
      name:Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
      name:College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA
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External Links {🔗}(2428)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

9.8s.