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We began analyzing https://www.dovepress.com/luteolin-inhibits-lung-metastasis-cell-migration-and-viability-of-trip-peer-reviewed-fulltext-article-BCTT, but it redirected us to https://www.dovepress.com/luteolin-inhibits-lung-metastasis-cell-migration-and-viability-of-trip-peer-reviewed-fulltext-article-BCTT. The analysis below is for the second page.

Title[redir]:
Luteolin inhibits lung metastasis, cell migration, and viability of tr | BCTT
Description:
Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells Matthew T Cook,1,2 Yayun Liang,1,2 Cynthia Besch-Williford,3 Salman M Hyder1,2 1Department of Biomedical Sciences, 2Dalton Cardiovascular Research Center, University of Missouri, 3IDEXX BioResearch, Columbia, MO, USA Abstract: Most breast cancer-related deaths from triple-negative breast cancer (TNBC) occur following metastasis of cancer cells and development of tumors at secondary sites. Because TNBCs lack the three receptors targeted by current chemotherapeutic regimens, they are typically treated with extremely aggressive and highly toxic non-targeted treatment strategies. Women with TNBC frequently develop metastatic lesions originating from drug-resistant residual cells and have poor prognosis. For this reason, novel therapeutic strategies that are safer and more effective are sought. Luteolin (LU) is a naturally occurring, non-toxic plant compound that has proven effective against several types of cancer. With this in mind, we conducted in vivo and in vitro studies to determine whether LU might suppress metastasis of TNBC. In an in vivo mouse metastasis model, LU suppressed metastasis of human MDA-MB-435 and MDA-MB-231 (4175) LM2 TNBC cells to the lungs. In in vitro assays, LU inhibited cell migration and viability of MDA-MB-435 and MDA-MB-231 (4175) LM2 cells. Further, LU induced apoptosis in MDA-MB-231 (4175) LM2 cells. Relatively low levels (10 µM) of LU significantly inhibited vascular endothelial growth factor (VEGF) secretion in MDA-MB-231 (4175) LM2 cells, suggesting that it has the ability to suppress a potent angiogenic and cell survival factor. In addition, migration of MDA-MB-231 (4175) LM2 cells was inhibited upon exposure to an antibody against the VEGF receptor, KDR, but not by exposure to a VEGF165 antibody. Collectively, these data suggest that the anti-metastatic properties of LU may, in part, be due to its ability to block VEGF production and KDR-mediated activity, thereby inhibiting tumor cell migration. These studies suggest that LU deserves further investigation as a potential treatment option for women with TNBC. Keywords: luteolin, triple-negative breast cancer, metastasis, cell migration, apoptosis, VEGF

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cells, mdamb, vegf, cell, cancer, migration, tnbc, breast, hours, metastasis, significantly, growth, luteolin, figure, human, anova, kdr, tumor, concentrations, receptor, inhibits, compared, lung, treated, antibody, usa, factor, assay, viability, sem, triplenegative, analysis, vehicle, study, animals, effect, treatment, apoptosis, endothelial, control, reduced, controls, low, vascular, reported, mrna, mice, colonies, significant, tumors,

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peer-reviewed cor grant specific pathogen-free conditions azoxymethane-induced colon carcinogenesis enzyme-linked immunosorbent assay suppresses tpa-induced mmp-9 mda-mb-435-derived lung colonies triple-negative breast cancer sterile-filtered dimethyl sulfoxide bio-rad laboratories imager lymph node–negative disease breast cancer-related deaths fluorescence-activated cell sorting anthracene-induced mammary tumors block vegf-induced angiogenesis dove medical press including fast-track processing hormone-responsive breast cancers endocrine-responsive breast cancer step rt-pcr system manuscript login erk/nf-κb signaling mmp-mediated vegf signaling phenol-based extraction method molecular research center drug-resistant residual cells cell line-dependent manner inhibits vascular expression promotes tumor growth mimics secondary-site colonization favored authors cell survival factor specific author lm2-inoculated mice received tnbc mda-mb-231 cells8 triple-negative counterparts breast-conserving therapy endothelial cell survival breast cancer subtypes 10 mg/kg lu reduced human breast tumours prostate tumor growth major angiogenic factor cell growth differ luteolin inhibits invasion began 5 days post-inoculation combat breast cancer primary breast cancer direct evidence shows triple-negative tumors pi3k–akt pathways

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