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We began analyzing https://www.tandfonline.com/doi/abs/10.4161/cbt.4.8.1917, but it redirected us to https://www.tandfonline.com/doi/abs/10.4161/cbt.4.8.1917. The analysis below is for the second page.

Title[redir]:
PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo: Cancer Biology & Therapy: Vol 4, No 8
Description:
Here, we examined the in vitro and in vivo anti-angiogenesis and anti-tumor activities of PE, a new marine-derived compound. Inhibition of angiogenesis was assessed in vitro using proliferation, mi...

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Keywords {🔍}

tumor, cells, taylor, francis, group, page, apoptosis, endothelial, cell, journals, vivo, open, inhibition, proliferation, hmecs, search, volume, access, research, antitumor, activities, vitro, angiogenesis, migration, adhesion, huvecs, mouse, induced, register, cancer, biology, therapy, issue, sulfated, saponin, sea, journal, article, citations, date, antiangiogenic, reprints, pdf, assays, petreated, cam, effect, examine, models, finally,

Topics {✒️}

induced dose-dependent suppression showed anti-proliferative activities twitter page taylor open francis group pe treatment suppressed receive personalised research journals books anti-tumor activities mouse sarcoma 180 exhibits anti-angiogenic anti-angiogenic activity anti-tumor activity marine-derived compound western blotting analyses tumor cell lines endothelial cell survival pe-treated hmecs suppressed spontaneous angiogenesis vivo fang tian endothelial cells comparable pe inhibited proliferation vivo anti-angiogenesis assess inhibition effect article https hepatoma 22 models date register tumor cells endothelial cells pe exerts results showed search physiological angiogenesis apoptosis assays triggering apoptosis increased apoptosis cell migration cell adhesion register add cart home sulfated saponin sea cucu sea cucumber xiongwen zhang yungyuang tong yanghua yi shilong zhang ling li published online tube-formation

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Schema {🗺️}

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            name:PE, a new sulfated saponin from sea cucu ....
ListItem:
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      name:Home
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      position:2
      name:All Journals
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      name:PE, a new sulfated saponin from sea cucu ....
PublicationIssue:
      id:#issue
      issueNumber:8
      datePublished:2005-08-01
      isPartOf:
         id:#periodical
         type:
            PublicationVolume
            Periodical
         name:Cancer Biology & Therapy
         issn:
            1538-4047
            1555-8576
         volumeNumber:4
         publisher:Taylor & Francis Group
["PublicationVolume","Periodical"]:
      id:#periodical
      name:Cancer Biology & Therapy
      issn:
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      volumeNumber:4
      publisher:Taylor & Francis Group
ScholarlyArticle:
      mainEntityOfPage:https://www.tandfonline.com/doi/full/10.4161/cbt.4.8.1917
      url:https://www.tandfonline.com/doi/full/10.4161/cbt.4.8.1917
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      sameAs:https://doi.org/10.4161/cbt.4.8.1917
      identifier:10.4161/cbt.4.8.1917
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      articleSection:Research Paper
      name:PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo
      headline:PE, a new sulfated saponin from sea cucumber, Exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo
      abstract:Here, we examined the in vitro and in vivo anti-angiogenesis and anti-tumor activities of PE, a new marine-derived compound. Inhibition of angiogenesis was assessed in vitro using proliferation, migration, adhesion, tube-formation and apoptosis assays in PE-treated HMECs and HUVECs. In vivo, CAM assays were used to assess inhibition effect of PE on physiological angiogenesis, and immunofluorescent microscopy was used to examine tumor microvessel density and apoptosis in PE-treated mouse tumor models. Finally, Western blotting analyses were performed to examine the effect of PE on VEGF signaling in HMECs. The results showed that PE inhibited proliferation of HMECs and HUVECs with IC50 values of 2.22Â°Â¿0.31 ?M and 1.98Â°Â¿0.32 ?M, induced endothelial cell apoptosis at concentrations &lt; 2 ?M, induced dose-dependent suppression of cell migration, cell adhesion and tube formation in HMECs and HUVECs, and showed anti-proliferative activities against several tumor cell lines (IC50 values of ~ 4 ?M). In vivo, PE (5 nM/egg) suppressed spontaneous angiogenesis in our CAM assay, and induced marked growth inhibition in mouse sarcoma 180 and hepatoma 22 models. Specifically, PE treatment reduced mouse sarcoma 180 tumor volume by triggering apoptosis of both tumor and tumor-associated endothelial cells, preferentially targeting on endothelial cells comparable with tumor cells. Finally, PE treatment suppressed the active (phosphorylated) forms of VEGFR2, Akt, ERK, FAK and paxillin, which are involved in endothelial cell survival, proliferation, adhesion and migration. Our results indicate that PE exerts an anti-angiogenic activity associated with inhibition of VEGFR2 signaling, and an anti-tumor activity associated with decreased proliferation of tumor cells and increased apoptosis of both endothelial cells and tumor cells.
      description:Here, we examined the in vitro and in vivo anti-angiogenesis and anti-tumor activities of PE, a new marine-derived compound. Inhibition of angiogenesis was assessed in vitro using proliferation, migration, adhesion, tube-formation and apoptosis assays in PE-treated HMECs and HUVECs. In vivo, CAM assays were used to assess inhibition effect of PE on physiological angiogenesis, and immunofluorescent microscopy was used to examine tumor microvessel density and apoptosis in PE-treated mouse tumor models. Finally, Western blotting analyses were performed to examine the effect of PE on VEGF signaling in HMECs. The results showed that PE inhibited proliferation of HMECs and HUVECs with IC50 values of 2.22Â°Â¿0.31 ?M and 1.98Â°Â¿0.32 ?M, induced endothelial cell apoptosis at concentrations &lt; 2 ?M, induced dose-dependent suppression of cell migration, cell adhesion and tube formation in HMECs and HUVECs, and showed anti-proliferative activities against several tumor cell lines (IC50 values of ~ 4 ?M). In vivo, PE (5 nM/egg) suppressed spontaneous angiogenesis in our CAM assay, and induced marked growth inhibition in mouse sarcoma 180 and hepatoma 22 models. Specifically, PE treatment reduced mouse sarcoma 180 tumor volume by triggering apoptosis of both tumor and tumor-associated endothelial cells, preferentially targeting on endothelial cells comparable with tumor cells. Finally, PE treatment suppressed the active (phosphorylated) forms of VEGFR2, Akt, ERK, FAK and paxillin, which are involved in endothelial cell survival, proliferation, adhesion and migration. Our results indicate that PE exerts an anti-angiogenic activity associated with inhibition of VEGFR2 signaling, and an anti-tumor activity associated with decreased proliferation of tumor cells and increased apoptosis of both endothelial cells and tumor cells.
      author:
            type:Person
            name:Yanghua Yi
            type:Person
            name:Ling Li
            type:Person
            name:Yungyuang Tong
            type:Person
            name:Liping Lin
            type:Person
            name:Shilong Zhang
            type:Person
            name:Fang Tian
            type:Person
            name:Xiongwen Zhang
            type:Person
            name:Jian Ding
            type:Person
            name:Peng Sun
            type:Person
            name:Jian Ding
      pageStart:874
      pageEnd:882
      datePublished:2005-09-23
      publisher:
         type:Organization
         name:Taylor & Francis
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Person:
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      name:Ling Li
      name:Yungyuang Tong
      name:Liping Lin
      name:Shilong Zhang
      name:Fang Tian
      name:Xiongwen Zhang
      name:Jian Ding
      name:Peng Sun
      name:Jian Ding
Organization:
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ImageObject:
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