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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers

We began analyzing https://www.spandidos-publications.com/10.3892/or.2012.2056, but it redirected us to https://www.spandidos-publications.com/10.3892/or.2012.2056. The analysis below is for the second page.

Title[redir]:
Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft
Description:
Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus, a medicinal plant that possesses antitumorigenic properties. Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. The results showed that formononetin downregulated the expression of the key pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases. We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. The potential anti-angiogenic effect of formononetin was examined in nude mouse xenografts. The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. The serum VEGF level was also reduced in the drug-treated animals when compared to the controls. These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 75,573,390 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

tumor, cancer, formononetin, cells, cell, article, view, google, scholar, pubmedncbi, colon, vegf, mmp, angiogenesis, human, expression, growth, invasion, control, astragalus, metastasis, effects, mice, effect, colorectal, study, animals, matrix, nude, formononetintreated, total, treatment, inhibition, protein, fig, xenografts, results, factor, drug, serum, proliferation, experimental, proapoptotic, invasiveness, activity, apoptosis, dmso, journal, information, antiangiogenic,

Topics {✒️}

female balb/c-nu/nu mice shi-quan-da-bu-tang pi3k-akt signaling pathway real-time reverse transcriptase-pcr 1021-335x online issn m-mlv reverse transcriptase serum-free culture medium possesses anti-inflammatory activity platelet-derived growth factor transforming growth factor-β possesses anti-inflammatory properties pro-angiogenic signals dominate anti-angiogenic signals released home submit manuscript traditional chinese medicine real-time rt-pcr pro-angiogenic factors occurred basement membrane-degrading enzymes promote caspase-dependent apoptosis erk-mediated p16 expression visible pcna-labeled cells formononetin initiates growth-inhibitory pro-apoptotic effect exhibited anti-vegf monoclonal antibody key pro-angiogenic factors strong pro-apoptotic agent mendeley abstract formononetin potential anti-angiogenic effect human colorectal carcinoma arachidonic acid metabolism potential chemotherapeutic/adjuvant agent cell cycle arrest formononetin-treated hct-116 cells oncology molecular central arterial stiffness regulating lipid metabolism herbal isoflavonoid isolated clinical oncology experimental clin transl sci formononetin-induced downregulation law pc pro-apoptotic activities tumor epithelial cells characterized angiogenic factor formononetin-treated nude mice total isoflavonoid extract pro-angiogenic signals unfavorable prognostic factor matrix metalloproteinase inhibitors nat rev cancer

Questions {❓}

  • Beck V, Rohr U and Jungbauer A: Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?

Social Networks {👍}(4)

External Links {🔗}(207)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • Fancybox
  • jQuery
  • jQuery module (jquery-3.4.1)
  • jQuery module (jquery-migrate-3.1.0)
  • jQuery module (jquery.fancybox)
  • jQuery module (jquery.jgrowl)
  • jQuery module (jquery.simplemodal)
  • Modernizr

Emails and Hosting {✉️}

Mail Servers:

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Name Servers:

  • josh.ns.cloudflare.com
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