
NCBI . NLM . NIH . GOV {
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Title[redir]:
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation - PMC
Description:
Hypoxia-inducible factor (HIF)-1α and HIF-2α are the main regulators of cellular responses to hypoxia. Post-translational modifications of HIF-1α and 2α are necessary to modulate their functions. The methylation of non-histone proteins by Set7, an ...
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Keywords {🔍}
set, hifα, doi, cells, pubmed, google, scholar, methylation, activity, figure, cell, pmc, hypoxia, article, protein, expression, free, assays, setshrna, rcc, lysine, knockdown, wildtype, hekt, overexpression, factor, glucose, antibody, hypoxiainducible, mutant, reporter, performed, hypoxic, target, transcriptional, acids, conditions, semiquantitative, methylated, increased, pcr, hif, gene, realtime, revealed, effect, biol, control, amino, role,
Topics {✒️}
basic-helix-loop-helix-pas heterodimer regulated lentivirus vector phage-cmv-mcs-izsgreen anti-hif-1αk32me antibody [anti-hif-1α semi-quantitative rt-pcr assays enhance poly-adp-ribose formation nucl-cyto-mem preparation kit dot-blot assays [anti-hif-1α interleukin-6/gp130/stat-3 signaling pathway hypoxia-inducible factor-1alpha reduces bacterial-purified hif-1α fragment harbor wild-type hif-2α hif-1α-mediated glucose homeostasis vhl-dependent hif-1α degradation anti-ha agarose beads wild-type human hif-1α wild-type human hif-2α hif-1α/2α transcriptional activity affect wild-type hif-2α von hippel-lindau disease gst-tagged hif-1α domains maintain tissue integrity/homeostasis hypoxia-inducible factor 2alpha set7-mediated hif-α methylation hif-1α increased constantly hypoxia-inducible factor-1alpha hypoxia-inducible factor induction hif-1α downstream targets hif-1α-k32-me1 peptide suppress hif-1α activity pmc beta search partial human hif-1α hypoxia-induced cell death hypoxia-inducible transcription factors hypoxia-inducible factor hif defined hypoxia-induced genes wild-type hif-1α hif-1α nuclear translocation hif-α underwent mutation anti-hif-1α antibody hif-1α target genes wild-type hif-2α hif-1α transcriptional activity hif-1alpha-mediated apoptosis defined hif-2α targets wild-type mef cells cdk1 stabilizes hif-1alpha decreasing dna-binding activity hif-2α target genes diminish hif-1α occupancy defined hypoxia-induced reporter
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- https://doi.org/10.1073/pnas.1311249111's financial summary
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