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  1. Analyzed Page
  2. Matching Content Categories
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We began analyzing https://koreascience.or.kr/article/JAKO201621650893987.page, but it redirected us to https://koreascience.or.kr/article/JAKO201621650893987.page. The analysis below is for the second page.

Title[redir]:
Scabraside D Derived from Sea Cucumber Induces Apoptosis and Inhibits Metastasis via iNOS and STAT-3 Expression in Human Cholangiocarcinoma Xenografts -Asian Pacific Journal of Cancer Prevention | Korea Science
Description:
Scabraside D, a sulfated triterpene glycoside, was extracted from the sea cucumber Holothuria scabra. It shows anti-proliferation in many of cancer cell lines, but the function and mechanisms of action of scabraside D in human cholangiocarcinoma (HuCCA) have not previously determined. In this study, we investigated the activity of scabraside D on HuCCA cell apoptosis, lymphangiogenesis and metastasis in a nude mouse model. Scabraside D induced signs of apoptosis, such as cell shrinkage, nuclear condensation, nuclear fragmentation and DNA fragmentation on TUNEL assays, while effectively decreasing expression of BCl-2 but increasing caspase-3 gene level expression. Immunohistochemistry revealed that scabraside D significantly reduced lymphatic vessel density (LVD). Moreover, scabraside D treatment significantly decreased VEGF-C, MMP-9 and uPA gene expression, which play important roles in the lymphangiogenesis and invasion of cancer cells in metastasis processes. Quantitative real-time PCR showed that scabraside D significantly decreased iNOS and STAT-3 gene expression. This study demonstrated that scabraside D plays a role in activation of HuCCA tumor apoptosis and inhibition of lymphangiogenesis, invasion and metastasis through decreasing BCl-2, MMP-9, uPA and VEGF-C and increasing caspase-3 expression by suppression of iNOS and STAT-3 expression. Therefore, scabraside D could be a promising candidate for cholangiocarcinoma treatment.

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Custom-built

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What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


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We don't see any clear sign of profit-making.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

cancer, expression, cell, scabraside, sea, human, tumor, metastasis, nitric, cholangiocarcinoma, invasion, oxide, cucumber, apoptosis, stat, res, httpsdoiorg, angiogenesis, synthase, inos, cells, zhang, science, lymphangiogenesis, gene, lymphatic, role, biol, clin, med, carcinoma, matrix, prevention, veterinary, triterpene, activity, bcl, significantly, activation, factor, growth, vegf, int, inducible, article, induces, faculty, mahidol, university, holothuria,

Topics {✒️}

lanostane-type triterpene oligoglycosides design target-specific primers stat-3 gene expression nitric oxide production increasing caspase-3 expression marine natural products upa gene expression lymphatic vessel density invasive breast carcinomas chem pharma bull human prostate carcinoma shows anti-proliferation exhibits anti-angiogenic mol med today exp ther med enhances bcl-2 expression type iv collagen transitional cell carcinoma chin herb med asian pacific journal nude mouse model play important roles 3390/md12084439 carpenter rl 1021/np0106236 choi hj biochim biophys acta orthotopic mouse model 088 haswell-elkins mr opisthorchis viverrini infection thai medicinal plants curcumin suppresses proliferation 1093/carcin/bgr032 sanceau rna interference triggers migratory-adhesive switch m304300200 song z polymerase chain reaction lung cancer suuvival future med chem anti-tumor effects sea cucumbers belonging regulates vegf expression human gynecological cancer effectively decreasing expression anti-tumor activities nitric oxide programmed cell death significantly decreased inos sulfated triterpene glycoside antifungal triterpene glycosides decrease tumor burden ben-sasson sa

Questions {❓}

  • Attoub S, Arafat K, G?

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