
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition - PMC
Description:
Hypoxia inducible factor 1α (HIF-1α) is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi) block tumor angiogenesis through the ...
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Keywords {🔍}
hifα, saha, protein, expression, silencing, cells, hdac, cell, treatment, huh, pubmed, figure, analysis, google, scholar, doi, data, translation, eifg, control, gapdh, levels, pmc, sahamediated, article, cancer, free, shown, reduction, mrna, immunoblot, dmso, level, eif, presence, lysates, factor, histone, effect, sirnamediated, response, scr, bar, hdaci, observed, relative, determined, usa, tif, twotailed,
Topics {✒️}
prolyl-hydroxylases/vhl-mediated proteasomal degradation z-leu-leu-leu-al anti-human hif-1α antibody high-resolution copy-number analysis mtor/p70s6k/4e-bp1 pathway [54] hypoxia inducible factor-1alpha hypoxia-inducible factor 1alpha small-molecule hif-1α inhibitors mouse anti-human hsp90 mouse anti-human gapdh hypoxia inductible factor-1α igf-ir signaling pathway rabbit anti-human eif3h mouse anti-human p53 regulates hif-1α translation hsp70/hsp90 chaperone axis anti-tia-1/tiar antibodies rabbit anti-human hdac7 pmc beta search n-terminal lysine residues controls hif-1α translation promising anti-tumor drug tia-1/tiar protein expression autoregulatory oxygen-sensing system atp-dependent rna helicase hypoxia-inducible factor-1 decreasing hif-1α expression promising anti-cancer drugs hif-1α expression relative ubiquitin-independent proteasomal degradation t-cell intracellular antigen-1 hif-1α protein levels cellular hif-1α levels hif-1α protein expression prk5-myc expression plasmid constitutively expressed hif-1β anti-myc tag antibodies vorinostat-responsive signaling pathways hif-1α acts independently multi-kinase inhibitor sorafenib increased hif-1α expression etiology-dependent molecular mechanisms growth factor stimulation mtorc1/4e-bp1 pathway hif-1α mrna levels hypoxia-mediated drug resistance tia-1/tiar stress granules hif-1α clearance pathways tia-1 mrna-binding proteins affect hif-1α expression
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- Boumber Y, Issa JP (2011) Epigenetics in cancer: what’s the future?
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