
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways - PMC
Description:
Hepatocellular carcinoma (HCC) is the fourth largest cause of cancer-related deaths worldwide with limited therapeutic interventions. Renewed interest in natural products as drug leads has resulted in a paradigm shift toward the rapid screening of ...
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ππ Tremendous Traffic: 10M - 20M visitors per month
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Keywords {π}
cells, cell, google, scholar, doi, hcc, hepg, pubmed, mapk, cancer, treatment, tumor, hepatocellular, carcinoma, apoptosis, pmc, effects, growth, control, figure, article, free, pathway, smmc, manner, figures, angiogenesis, data, expression, invasion, signaling, results, endothelial, treated, performed, migration, proliferation, ratreated, observed, acid, study, mice, assay, phosphop, levels, death, aktmtor, natural, vitro, formation,
Topics {βοΈ}
annexin v-fitc/pi staining annexin v-fitc/pi experiments uplc/q-tof-ms/ms targeting pi3k/akt/mtor pathway anchorage-independent growth assay extracellular signal-regulated kinase pi3k/akt/mtor pathway activation pi3k/akt/mtor pathway regulates pmc beta search form 3d-tubular structures clonogenic/colony formation assay +ve/pi +ve quadrants erk-induced cell deathβapoptosis fitc/pi staining fitc/pi staining dna-bound propidium iodide endothelial cell-mediated angiogenesis sun yat-sen university ras/raf/mek/erk extracellular matrix-independent survival pi3k/akt signalling pathways c-terminal binding protein pro-survival pathway molecules cancer-related deaths worldwide pi3k/akt/mtor pathway akt-mtorc1-rps6 signaling clear cut time-dependent cis platin-induced apoptosis data availability statement ethics statement tube formation assay anchorage-independent manner akt/mtor pathway proteins phospho-mtor/mtor ratio cell type-specific manner produced cell death phospho-p44/42 mapk increased phospho-p44/42 mapk expression pathogen-free conditions phospho-p38 mapk increased ra-treated hepg2 cells phospho-p38 mapk expression +ve/pi βve matrigel-coated transwell assays downregulating mmp-2/mmp-9 secretion soft agar colonies ra-treated hcc cells colony forming ability p38 map kinase p38 map kinase
Questions {β}
- Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?
- Drug discovery and natural products: end of an era or an endless frontier?
- Plant natural products: back to the future or into extinction?
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- Earnings of https://doi.org/10.1097/01.tp.0000252780.42104.95
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Transplantation.&title=Mammalian%20target%20of%20rapamycin%20pathway%20activity%20in%20hepatocellular%20carcinomas%20of%20patients%20undergoing%20liver%20transplantation&author=W%20Sieghart&author=T%20Fuereder&author=K%20Schmid&author=D%20Cejka&author=J%20Werzowa&volume=83&publication_year=2007&pages=425-32&pmid=17318075&doi=10.1097/01.tp.0000252780.42104.95&?
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- Financial intake of https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res.&title=mTOR%20and%20P70%20S6%20kinase%20expression%20in%20primary%20liver%20neoplasms&author=F%20Sahin&author=R%20Kannangai&author=O%20Adegbola&author=J%20Wang&author=G%20Su&volume=10&publication_year=2004&pages=8421-5&pmid=15623621&doi=10.1158/1078-0432.CCR-04-0941&
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- How much does https://scholar.google.com/scholar_lookup?journal=Expert%20Opin%20Ther%20Targets.&title=The%20RAS/RAF/MEK/ERK%20and%20the%20PI3K/AKT%20signalling%20pathways:%20role%20in%20cancer%20pathogenesis%20and%20implications%20for%20therapeutic%20approaches&author=A%20De%20Luca&author=MR%20Maiello&author=A%20D'Alessio&author=M%20Pergameno&author=N%20Normanno&volume=16&issue=Suppl.%202&publication_year=2012&pages=S17-27&pmid=22443084&doi=10.1517/14728222.2011.639361& make?
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- https://doi.org/10.1016/j.molmed.2004.01.007's financial summary
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Trends%20Mol%20Med.&title=p38%20MAP%20kinase:%20a%20convergence%20point%20in%20cancer%20therapy&author=JM%20Olson&author=AR%20Hallahan&volume=10&publication_year=2004&pages=125-9&pmid=15102355&doi=10.1016/j.molmed.2004.01.007& bring in?
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