Here's how DOI.ORG makes money* and how much!

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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers

We began analyzing https://www.spandidos-publications.com/10.3892/or.2015.4445, but it redirected us to https://www.spandidos-publications.com/10.3892/or.2015.4445. The analysis below is for the second page.

Title[redir]:
Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway Corrigendum in /10.3892/or.2024.8793
Description:
Hispolon has been shown to have anticancer effects on various tumors. However, whether hispolon exerts anti-migration activity in breast cancer cells and the underlying mechanisms, have not been elucidated yet. In the present study, our data demonstrated that hispolon inhibited TPA-induced breast cancer MCF-7 cell migration at sub-toxic concentrations in vitro. Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug. Furthermore, N-acetyl-cysteine, an antioxidant agent, markedly suppressed TPA-induced epithelial-to-mesenchymal transition, cell migration and activation of ERK. Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E‑cadherin pathway. Hispolon may be developed as a potential antimetastasis agent to breast cancer.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 75,579,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

cells, hispolon, cancer, tpa, ros, tpainduced, breast, cell, ecadherin, article, view, pubmedncbi, google, scholar, expression, slug, mcf, emt, snail, signaling, migration, treatment, erk, akt, levels, human, metastasis, protein, pathway, mapk, nac, fig, activation, tumor, results, ngml, production, transition, inhibited, western, inhibits, kinase, intracellular, effect, blotting, shown, study, involved, pretreated, present,

Topics {✒️}

ros/erk/slug/e-cadherin pathway corrigendum ros/erk/slug/e-cadherin signaling pathway inhibiting ros/erk/slug/e-cadherin pathway c-jun n-terminal kinase long-term oxidative stress tpa-induced e-cadherin downregulation 1021-335x online issn inhibiting matrix metallo-proteinase-2/9 inhibit tpa-induced migration tpa-induced cell migration tpa-induced icam-1 expression tnf-α-induced emt mdm2-recruited erk1/2 activity ros-mediated mitochondrial pathway ros-mediated signaling cascade affect tpa-induced phosphorylation mitogen-activated protein kinase recovering e-cadherin activity special kinase inhibitors extracellular signal-regulated kinase tpa-induced increasing levels e-cadherin protein levels zinc finger proteins epithelial-mesenchymal transition reminiscent estrogen receptor alpha e-cadherin transcriptional repressors tpa-induced ros production exert anti-migration activity rac1/ros-dependent secretion downregulate e-cadherin expression e-cadherin gene expression home submit manuscript ros-erk signaling pathway tpa-induced ros generation repressed tpa-induced phosphorylation downregulates e-cadherin e-cadherin expression caused nf-κb signaling pathway advanced breast cancer ros-dependent erk activation suppressing nf-κb activation tpa-induced morphologic change mendeley abstract hispolon mda-mb-231 cells e-cadherin induced tpa-induced migration reactive oxygen species clinical oncology experimental human breast cancer tpa-induced activation

Questions {❓}

  • Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Social Networks {👍}(4)

External Links {🔗}(240)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • Fancybox
  • jQuery
  • jQuery module (jquery-3.4.1)
  • jQuery module (jquery-migrate-3.1.0)
  • jQuery module (jquery.fancybox)
  • jQuery module (jquery.jgrowl)
  • jQuery module (jquery.simplemodal)
  • Modernizr

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com
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