
NCBI . NLM . NIH . GOV {
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Title[redir]:
Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine - PMC
Description:
Development of chemoresistance, poor prognosis, and metastasis often renders the current treatments for colorectal cancer (CRC) ineffective. Whether ursolic acid (UA), a component of numerous medicinal plants, either alone or in combination with ...
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Keywords {🔍}
cancer, doi, capecitabine, crc, cells, tumor, google, scholar, mice, pubmed, metastasis, cell, acid, ursolic, proliferation, effect, combination, fig, growth, human, activation, expression, inhibits, treatment, hct, nfκb, colorectal, tumors, panel, inhibited, found, mmp, apoptosis, results, inhibition, effects, control, significant, group, drug, examined, vegf, multiple, lines, assay, proteins, bonferroni, day, pmc, nude,
Topics {✒️}
silica-based c18 column spot-rtke digital camera unilateral hand-foot syndrome numerous medicinal plants d-luciferin potassium salt induces ca2+ release pmc beta search cxcr4/cxcl12 signaling axis mitochondrial dye-uptake assay wild-type k-ras assess nf-κb activation live/dead assay kit suppress crc-induced ascites constitutive nf-κb activation inhibit activated nf-κb ua inhibits nf-κb live/dead apoptosis assay cytochrome p450 activities nf-kappab addiction nuclear beta-catenin overexpression ursolic acid-induced marginal dose-effect curve disease-free survival luciferase-transfected hct116 cells spot advanced software human colorectal carcinoma multiple signaling pathway male wistar rats orthotopic nude-mice model multiple comparison adjustments mitochondrial intrinsic pathway including breast cancer nuclear factor-kappa multiple signaling pathways human colon cancer license information pmcid mutant k-ras ursolic acid derived ursolic acid derivatives ursolic acid leads serum-free medium targeting inflammatory pathways orthotopic mouse model stat3 signaling pathway tumor necrosis factor mouse prostate model multiple cell lines clin cancer res including colorectal cancer nf-κb activation
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