We are analyzing https://link.springer.com/article/10.1186/s12935-021-02366-0.

Title:
Induction and application of ferroptosis in cancer therapy | Cancer Cell International
Description:
At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway. In the past few years, ferroptosis has been shown to induce tumor cell death, providing new ideas for tumor treatment. In this article, we summarize the latest advances in ferroptosis-induced tumor therapy at the intersection of tumor biology, molecular biology, redox biology, and materials chemistry. First, we state the characteristics of ferroptosis in cells, then introduce the key molecular mechanism of ferroptosis, and describes the relationship between ferroptosis and oxidative stress signaling pathways. Finally, we focused on several types of ferroptosis inducers discovered by scholars, and the application of ferroptosis in systemic chemotherapy, radiotherapy, immunotherapy and nanomedicine, in the hope that ferroptosis can exert its potential in the treatment of tumors.
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Keywords {🔍}

ferroptosis, pubmed, cancer, article, google, scholar, cells, cell, cas, iron, central, lipid, death, peroxidation, treatment, gpx, tumor, therapy, induce, biol, ros, gsh, resistance, inhibit, expression, addition, liu, anticancer, promote, membrane, erastin, slca, pathway, activity, drugs, zhang, growth, chen, metabolism, nrf, fins, nat, wang, increase, cancers, class, found, mechanism, fig, drug,

Topics {✒️}

folate-metabolising gene cystathionine-beta-synthase fda-approved ultra-small poly p62-keap1-nrf2 pathway protects fda-approved anti-cancer drug oncogenic-ras-harboring cancer cells xiao li & xuedong fang article download pdf genotype-selective antitumor agents fda-approved immunosuppressant sulfasalazine friedmann angeli jp delicate high-energy state ferroptosis-related nano-preparations combined diarylamine radical-trapping antioxidants targeting hmg-coa reductase anti-cancer drug approved mitochondrial dna-targeted photochemotherapy aif-mediated cell death inhibiting hmg-coa reductase haemin-induced cell death supramolecular photosensitizer-inducer nanodrug ferroportin-mediated iron accumulation central downstream regulator infrared light-mediated enhancement high-efficiency anticancer therapy p53-mediated tumour suppression bypass chemoresistance-related pathways nutrient-deprived cancer cells acid-activated reducing agent glioma-induced brain edema ferrous ammonium sulfate promising anti-cancer drug oxygen-boosted phototherapy based escrt-iii acts downstream continuous large-scale oxidation infrared-assisted fenton reaction small-cell lung cancer small-cell lung cancer ferroptosis-induced tumor therapy sorafenib-mediated cancer therapy significant anti-cancer effect reactive oxygen species prevent p53-induced ferroptosis cystathionine-gamma-lyase function traditional anti-cancer drugs kras-driven pancreatic cancers cancer search search prevent hydroperoxide-induced ferroptosis xc- cystine/glutamate antiporter emerging anti-cancer strategy arginine succinate synthase

Questions {❓}

Artemisinin and its derivatives as a repurposing anticancer agent: what else do we need to do?
The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?
Unsolved mysteries: how does lipid peroxidation cause ferroptosis?

Schema {🗺️}

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