
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Iron Metabolism in Ferroptosis - PMC
Description:
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the ...
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Keywords {๐}
ferroptosis, iron, pubmed, google, scholar, doi, cell, cells, pmc, free, article, slca, death, cancer, ferroptotic, role, lipid, peroxidation, tfrc, activity, mitochondrial, ferritin, protein, cisd, pcbp, family, member, degradation, gao, expression, metabolism, hmox, mice, chen, kang, wang, liver, erastininduced, tang, damage, diseases, autophagy, proteins, sun, biol, irondependent, uptake, accumulation, heme, receptor,
Topics {โ๏ธ}
p62-keap1-nrf2 pathway protects oncogenic-ras-harboring cancer cells cigarette smoke-induced ferroptosis impaired g-proteinโcoupled receptor pmc beta search heme/iron-related metabolic pathways haemin-induced cell death gpx4-independent anti-ferroptosis pathways long-chain polyunsaturated coas valent iron-based nanotherapeutics powerful nf-kappab inhibitor sulfasalazine-induced cell death doxorubicin-induced ferroptotic damage rsl3-induced cell death crucial pro-ferroptotic regulator mitochondrial iron-mediated immunometabolism pro-drug converted intracellularly autophagy-dependent cell death suppresses erastin-induced ferroptosis hypoxia-inducible factor ameliorates erastin-induced ferroptosis fbxl5-mediated proteasomal degradation lysosome-dependent degradation system exhibit anti-inflammatory effects n-terminal transactivation domain gpx4 inhibitor-induced ferroptosis free reactive iron iron-dependent lipid peroxidation activators include dihydroartemisinin iron-mediated lipid peroxidation iron-free apotransferrin iron-loaded pcbp2 loses sh-sy5h neuroblastoma cells parkin-overexpressed ht1080 cells ferroptosis-induced liver fibrosis anti-ferroptotic regulator gpx4 ferroptosis-mediated liver fibrosis endogenous pro-ferroptosis molecule testicular ischemia-reperfusion injury membrane-permeable iron chelator iron-dependent oxidative damage limits cystine starvation iron-mediated ros production glutathione-independent ferroptosis suppressor iron-related pathological conditions piperazine erastin-treated cells ubiquitin-proteasome system ferroptotic cell death human l-ferritin deficiency anti-lipid peroxidation activity
Questions {โ}
- Autophagy and Ferroptosis - Whatโs the Connection?
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- Get to know https://scholar.google.com/scholar_lookup?journal=Biomater.%20Sci.&title=Assessment%20of%20zero-valent%20iron-based%20nanotherapeutics%20for%20ferroptosis%20induction%20and%20resensitization%20strategy%20in%20cancer%20cells.&author=K.%20J.%20Huang&author=Y.%20H.%20Wei&author=Y.%20C.%20Chiu&author=S.%20R.%20Wu&author=D.%20B.%20Shieh&volume=7&publication_year=2019&pages=1311-1322&pmid=30734774&doi=10.1039/c8bm01525b&'s earnings
- Monthly income for https://doi.org/10.1016/j.transci.2018.05.028
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Transfus%20Apher.%20Sci.&title=Haemin-induced%20cell%20death%20in%20human%20monocytic%20cells%20is%20consistent%20with%20ferroptosis.&author=S.%20Imoto&author=M.%20Kono&author=T.%20Suzuki&author=Y.%20Shibuya&author=T.%20Sawamura&volume=57&publication_year=2018&pages=524-531&pmid=29859670&doi=10.1016/j.transci.2018.05.028&
- What's the profit of https://doi.org/10.1073/pnas.95.9.4924?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20U.S.A.&title=Iron-dependent%20oxidation,%20ubiquitination,%20and%20degradation%20of%20iron%20regulatory%20protein%202:%20implications%20for%20degradation%20of%20oxidized%20proteins.&author=K.%20Iwai&author=S.%20K.%20Drake&author=N.%20B.%20Wehr&author=A.%20M.%20Weissman&author=T.%20LaVaute&volume=95&publication_year=1998&pages=4924-4928&pmid=9560204&doi=10.1073/pnas.95.9.4924&
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet.&title=A%20missense%20mutation%20in%20TFRC,%20encoding%20transferrin%20receptor%201,%20causes%20combined%20immunodeficiency.&author=H.%20H.%20Jabara&author=S.%20E.%20Boyden&author=J.%20Chou&author=N.%20Ramesh&author=M.%20J.%20Massaad&volume=48&publication_year=2016&pages=74-78&pmid=26642240&doi=10.1038/ng.3465& produce monthly?
- What is the monthly revenue of https://doi.org/10.1016/j.cmet.2015.05.002?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Cell%20Metab.&title=SLC39A14%20is%20required%20for%20the%20development%20of%20hepatocellular%20iron%20overload%20in%20murine%20models%20of%20hereditary%20hemochromatosis.&author=S.%20Jenkitkasemwong&author=C.%20Y.%20Wang&author=R.%20Coffey&author=W.%20Zhang&author=A.%20Chan&volume=22&publication_year=2015&pages=138-150&pmid=26028554&doi=10.1016/j.cmet.2015.05.002& each month?
- What's the profit of https://doi.org/10.1038/nchembio.2238?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Nat.%20Chem.%20Biol.&title=Oxidized%20arachidonic%20and%20adrenic%20PEs%20navigate%20cells%20to%20ferroptosis.&author=V.%20E.%20Kagan&author=G.%20Mao&author=F.%20Qu&author=J.%20P.%20Angeli&author=S.%20Doll&volume=13&publication_year=2017&pages=81-90&pmid=27842066&doi=10.1038/nchembio.2238&
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Curr.%20Pathobiol.%20Rep.&title=Autophagy%20and%20Ferroptosis%20-%20What%E2%80%99s%20the%20Connection?&author=R.%20Kang&author=D.%20Tang&volume=5&publication_year=2017&pages=153-159&pmid=29038744&doi=10.1007/s40139-017-0139-5&?
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Front.%20Cell%20Dev.%20Biol.&title=Oxidative%20damage%20and%20antioxidant%20defense%20in%20ferroptosis.&author=F.%20Kuang&author=J.%20Liu&author=D.%20Tang&author=D.%20Kang&publication_year=2020&pmid=33043019&doi=10.3389/fcell.2020.586578& have monthly?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet.&title=Transferrin%20receptor%20is%20necessary%20for%20development%20of%20erythrocytes%20and%20the%20nervous%20system.&author=J.%20E.%20Levy&author=O.%20Jin&author=Y.%20Fujiwara&author=F.%20Kuo&author=N.%20C.%20Andrews&volume=21&publication_year=1999&pages=396-399&pmid=10192390&doi=10.1038/7727& produce monthly?
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- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Dev.%20Cell&title=PINK1%20and%20PARK2%20suppress%20pancreatic%20tumorigenesis%20through%20control%20of%20mitochondrial%20iron-mediated%20immunometabolism.&author=C.%20Li&author=Y.%20Zhang&author=X.%20Cheng&author=H.%20Yuan&author=S.%20Zhu&volume=46&issue=e8&publication_year=2018&pmid=30100261&doi=10.1016/j.devcel.2018.07.012&?
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Int.%20J.%20Mol.%20Med.&title=Ferroptosis%20is%20associated%20with%20oxygen-glucose%20deprivation/reoxygenation-induced%20Sertoli%20cell%20death.&author=L.%20Li&author=Y.%20Hao&author=Y.%20Zhao&author=H.%20Wang&author=X.%20Zhao&volume=41&publication_year=2018&pages=3051-3062&pmid=29436589&doi=10.3892/ijmm.2018.3469&
- https://doi.org/10.1172/jci.insight.90777's revenue stream
- How much income does https://scholar.google.com/scholar_lookup?journal=JCI%20Insight&title=Inhibition%20of%20neuronal%20ferroptosis%20protects%20hemorrhagic%20brain.&author=Q.%20Li&author=X.%20Han&author=X.%20Lan&author=Y.%20Gao&author=J.%20Wan&volume=2&issue=e90777&publication_year=2017&pmid=28405617&doi=10.1172/jci.insight.90777& have?
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- How much does https://doi.org/10.1371/journal.pone.0117435 bring in each month?
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=Systemic%20and%20cerebral%20iron%20homeostasis%20in%20ferritin%20knock-out%20mice.&author=W.%20Li&author=H.%20J.%20Garringer&author=C.%20B.%20Goodwin&author=B.%20Richine&author=A.%20Acton&volume=10&issue=e0117435&publication_year=2015&pmid=25629408&doi=10.1371/journal.pone.0117435& gross monthly?
- See how much https://doi.org/10.1016/j.chembiol.2020.02.005 makes per month
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Cell%20Chem.%20Biol.&title=Autophagy-dependent%20ferroptosis:%20machinery%20and%20regulation.&author=J.%20Liu&author=F.%20Kuang&author=G.%20Kroemer&author=D.%20J.%20Klionsky&author=R.%20Kang&volume=27&publication_year=2020&pages=420-435&pmid=32160513&doi=10.1016/j.chembiol.2020.02.005&
- How much does https://doi.org/10.1038/s41417-020-0182-y bring in each month?
- How much money does https://scholar.google.com/scholar_lookup?journal=Cancer%20Gene.%20Ther.&title=Interplay%20between%20MTOR%20and%20GPX4%20signaling%20modulates%20autophagy-dependent%20ferroptotic%20cancer%20cell%20death.&author=Y.%20Liu&author=Y.%20Wang&author=J.%20Liu&author=R.%20Kang&author=D.%20Tang&publication_year=2020&pmid=32457486&doi=10.1038/s41417-020-0182-y& generate?
- What's the monthly money flow for https://doi.org/10.1016/j.redox.2017.08.015?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Red.%20Biol.&title=Iron%20accumulation%20in%20senescent%20cells%20is%20coupled%20with%20impaired%20ferritinophagy,%20and%20inhibition%20of%20ferroptosis.&author=S.%20Masaldan&author=S.%20A.%20S.%20Clatworthy&author=C.%20Gamell&author=P.%20M.%20Meggyesy&author=A.%20T.%20Rigopoulos&volume=14&publication_year=2018&pages=100-115&pmid=28888202&doi=10.1016/j.redox.2017.08.015&?
- How much profit is https://doi.org/10.3324/haematol.2009.016824 making per month?
- https://scholar.google.com/scholar_lookup?journal=Haematologica&title=Deferasirox%20is%20a%20powerful%20NF-kappaB%20inhibitor%20in%20myelodysplastic%20cells%20and%20in%20leukemia%20cell%20lines%20acting%20independently%20from%20cell%20iron%20deprivation%20by%20chelation%20and%20reactive%20oxygen%20species%20scavenging.&author=E.%20Messa&author=S.%20Carturan&author=C.%20Maffe&author=M.%20Pautasso&author=E.%20Bracco&volume=95&publication_year=2010&pages=1308-1316&pmid=20534700&doi=10.3324/haematol.2009.016824& income
- https://doi.org/10.1371/journal.pgen.1008396's financial summary
- Monthly income for https://scholar.google.com/scholar_lookup?journal=PLoS%20Genet&title=Ferritin%20heavy%20chain%20protects%20the%20developing%20wing%20from%20reactive%20oxygen%20species%20and%20ferroptosis.&author=S.%20Mumbauer&author=J.%20Pascual&author=I.%20Kolotuev&author=F.%20Hamaratoglu&volume=15&issue=e1008396&publication_year=2019&pmid=31568497&doi=10.1371/journal.pgen.1008396&
- What are the earnings of https://doi.org/10.1016/j.cmet.2011.08.015?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab.&title=Activation%20of%20the%20HIF%20prolyl%20hydroxylase%20by%20the%20iron%20chaperones%20PCBP1%20and%20PCBP2.&author=A.%20Nandal&author=J.%20C.%20Ruiz&author=P.%20Subramanian&author=S.%20Ghimire-Rijal&author=R.%20A.%20Sinnamon&volume=14&publication_year=2011&pages=647-657&pmid=22055506&doi=10.1016/j.cmet.2011.08.015&?
- How much does https://doi.org/10.1074/jbc.RA119.009548 generate monthly?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=Ferroptosis%20is%20controlled%20by%20the%20coordinated%20transcriptional%20regulation%20of%20glutathione%20and%20labile%20iron%20metabolism%20by%20the%20transcription%20factor%20BACH1.&author=H.%20Nishizawa&author=M.%20Matsumoto&author=T.%20Shindo&author=D.%20Saigusa&author=H.%20Kato&volume=295&publication_year=2020&pages=69-82&pmid=31740582&doi=10.1074/jbc.RA119.009548&?
- How much revenue does https://doi.org/10.1038/90038 bring in?
- How much income does https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet.&title=A%20mutation%20in%20SLC11A3%20is%20associated%20with%20autosomal%20dominant%20hemochromatosis.&author=O.%20T.%20Njajou&author=N.%20Vaessen&author=M.%20Joosse&author=B.%20Berghuis&author=J.%20W.%20van%20Dongen&volume=28&publication_year=2001&pages=213-214&pmid=11431687&doi=10.1038/90038& have?
- https://doi.org/10.1016/j.phymed.2015.08.002's financial summary
- Revenue of https://scholar.google.com/scholar_lookup?journal=Phytomedicine&title=Artemisinin%20derivatives%20induce%20iron-dependent%20cell%20death%20(ferroptosis)%20in%20tumor%20cells.&author=E.%20Ooko&author=M.%20E.%20Saeed&author=O.%20Kadioglu&author=S.%20Sarvi&author=M.%20Colak&volume=22&publication_year=2015&pages=1045-1054&pmid=26407947&doi=10.1016/j.phymed.2015.08.002&
- What's the income generated by https://doi.org/10.1002/hep.31328 each month?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Hepatology&title=Iron%20chaperone%20PCBP1%20protects%20murine%20liver%20from%20lipid%20peroxidation%20and%20steatosis.&author=O.%20Protchenko&author=E.%20Baratz&author=S.%20Jadhav&author=F.%20Li&author=M.%20Shakoury-Elizeh&publication_year=2020&pmid=32438524&doi=10.1002/hep.31328&?
- What is the earnings of https://doi.org/10.1016/j.cellsig.2020.109633?
- https://scholar.google.com/scholar_lookup?journal=Cell%20Signal.&title=Ceruloplasmin%20suppresses%20ferroptosis%20by%20regulating%20iron%20homeostasis%20in%20hepatocellular%20carcinoma%20cells.&author=Y.%20Shang&author=M.%20Luo&author=F.%20Yao&author=S.%20Wang&author=Z.%20Yuan&volume=72&issue=109633&publication_year=2020&pmid=32283255&doi=10.1016/j.cellsig.2020.109633&'s total income per month
- How much does https://doi.org/10.1016/j.freeradbiomed.2018.10.426 generate monthly?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Free%20Radic.%20Biol.%20Med.&title=Nrf2%20inhibition%20reverses%20resistance%20to%20GPX4%20inhibitor-induced%20ferroptosis%20in%20head%20and%20neck%20cancer.&author=D.%20Shin&author=E.%20H.%20Kim&author=J.%20Lee&author=J.%20L.%20Roh&volume=129&publication_year=2018&pages=454-462&pmid=30339884&doi=10.1016/j.freeradbiomed.2018.10.426&
- What's the financial gain of https://doi.org/10.1016/j.bbrc.2016.10.068?
- Get to know https://scholar.google.com/scholar_lookup?journal=Biochem.%20Biophys.%20Res.%20Commun.&title=FANCD2%20protects%20against%20bone%20marrow%20injury%20from%20ferroptosis.&author=X.%20Song&author=Y.%20Xie&author=R.%20Kang&author=W.%20Hou&author=X.%20Sun&volume=480&publication_year=2016&pages=443-449&pmid=27773819&doi=10.1016/j.bbrc.2016.10.068&'s earnings
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- https://doi.org/10.1016/j.cell.2017.09.021 income
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Red.%20Biol.%20Dis.%20Cell&title=Ferroptosis:%20a%20regulated%20cell%20death%20nexus%20linking%20metabolism.&author=B.%20R.%20Stockwell&author=J.%20P.%20Friedmann%20Angeli&author=H.%20Bayir&author=A.%20I.%20Bush&author=M.%20Conrad&volume=171&publication_year=2017&pages=273-285&pmid=28985560&doi=10.1016/j.cell.2017.09.021&
- What's the financial gain of https://doi.org/10.1002/hep.28574?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Hepatology&title=Metallothionein-1G%20facilitates%20sorafenib%20resistance%20through%20inhibition%20of%20ferroptosis.&author=X.%20Sun&author=X.%20Niu&author=R.%20Chen&author=W.%20He&author=D.%20Chen&volume=64&publication_year=2016a&pages=488-500&pmid=27015352&doi=10.1002/hep.28574& bring in?
- How much money does https://doi.org/10.1002/hep.28251 generate?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Hepatology&title=Activation%20of%20the%20p62-Keap1-NRF2%20pathway%20protects%20against%20ferroptosis%20in%20hepatocellular%20carcinoma%20cells.&author=X.%20Sun&author=Z.%20Ou&author=R.%20Chen&author=X.%20Niu&author=D.%20Chen&volume=63&publication_year=2016b&pages=173-184&pmid=26403645&doi=10.1002/hep.28251&?
- What's the financial gain of https://doi.org/10.1038/onc.2015.32?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=HSPB1%20as%20a%20novel%20regulator%20of%20ferroptotic%20cancer%20cell%20death.&author=X.%20Sun&author=Z.%20Ou&author=M.%20Xie&author=R.%20Kang&author=Y.%20Fan&volume=34&publication_year=2015&pages=5617-5625&pmid=25728673&doi=10.1038/onc.2015.32&?
- https://doi.org/10.1172/jci.insight.132747 income
- How much profit is https://scholar.google.com/scholar_lookup?journal=JCI%20Insight&title=Mitochondria-dependent%20ferroptosis%20plays%20a%20pivotal%20role%20in%20doxorubicin%20cardiotoxicity.&author=T.%20Tadokoro&author=M.%20Ikeda&author=T.%20Ide&author=H.%20Deguchi&author=S.%20Ikeda&volume=5&issue=e132747&publication_year=2020&pmid=32376803&doi=10.1172/jci.insight.132747& making per month?
- Financial intake of https://doi.org/10.1038/s41422-019-0164-5
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Cell%20Res.&title=The%20molecular%20machinery%20of%20regulated%20cell%20death.&author=D.%20Tang&author=R.%20Kang&author=T.%20V.%20Berghe&author=P.%20Vandenabeele&author=G.%20Kroemer&volume=29&publication_year=2019&pages=347-364&pmid=30948788&doi=10.1038/s41422-019-0164-5&?
- Get to know what's the income of https://doi.org/10.1182/blood.v96.3.1113
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Blood&title=The%20molecular%20defect%20in%20hypotransferrinemic%20mice.&author=C.%20C.%20Trenor&author=D.%20R.%20Campagna&author=V.%20M.%20Sellers&author=N.%20C.%20Andrews&author=M.%20D.%20Fleming&volume=96&publication_year=2000&pages=1113-1118&pmid=10910930&doi=10.1182/blood.v96.3.1113&?
- How much money does https://doi.org/10.1182/blood-2010-11-319483 make?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Blood&title=Targeted%20deletion%20of%20the%20mouse%20Mitoferrin1%20gene:%20from%20anemia%20to%20protoporphyria.&author=M.%20B.%20Troadec&author=D.%20Warner&author=J.%20Wallace&author=K.%20Thomas&author=G.%20J.%20Spangrude&volume=117&publication_year=2011&pages=5494-5502&pmid=21310927&doi=10.1182/blood-2010-11-319483& each month?
- What's the monthly income of https://doi.org/10.1038/mp.2017.171?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Mol.%20Psychiatry&title=Tau-mediated%20iron%20export%20prevents%20ferroptotic%20damage%20after%20ischemic%20stroke.&author=Q.%20Z.%20Tuo&author=P.%20Lei&author=K.%20A.%20Jackman&author=X.%20L.%20Li&author=H.%20Xiong&volume=22&publication_year=2017&pages=1520-1530&pmid=28886009&doi=10.1038/mp.2017.171&
- See how much https://doi.org/10.1182/blood.v82.12.3610.bloodjournal82123610 makes per month
- https://scholar.google.com/scholar_lookup?journal=Blood&title=Desferrioxamine%20induces%20erythropoietin%20gene%20expression%20and%20hypoxia-inducible%20factor%201%20DNA-binding%20activity:%20implications%20for%20models%20of%20hypoxia%20signal%20transduction.&author=G.%20L.%20Wang&author=G.%20L.%20Semenza&volume=82&publication_year=1993&pages=3610-3615&pmid=8260699&doi=10.1182/blood.v82.12.3610.bloodjournal82123610&'s financial summary
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- How much does https://scholar.google.com/scholar_lookup?journal=Biochem.%20Biophys.%20Res.%20Commun.&title=NEDD4L-mediated%20LTF%20Protein%20degradation%20limits%20ferroptosis.&author=Y.%20Wang&author=Y.%20Liua&author=J.%20Liua&author=R.%20Kang&author=D.%20Tang&volume=531&publication_year=2020&pages=581-587&pmid=32811647&doi=10.1021/acschembio.7b01082& make?
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