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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, pubmed, google, scholar, mitochondrial, ptp, mitochondria, permeability, transition, pore, release, matrix, channel, pmc, bernardi, membrane, free, article, efflux, yeast, csa, uptake, opening, drosophila, cell, nature, calcium, cyclosporin, biol, chem, mice, petronilli, liver, potential, mammals, regulation, cyclophilin, ppif, mcu, pathways, death, cypd, biochem, mechanism, rate, open, lack, rat, febs, nlm,

Topics {✒️}

1400 nmol ca2+ mg−1 protein min−1 20 nmol ca2+ mg−1 protein min−1 rr-insensitive 3na+–ca2+ antiporter ca2+-induced large-amplitude swelling cyclosporin a-sensitive channel open-closed transitions depending ubiquinone-binding site regulates corona-de-la-peña pmc beta search rr-sensitive ca2+ uniporter ion-conducting channels similar preventing calcineurin-dependent dephosphorylation acute ischemia-reperfusion injury mitochondrial na+/ca2+ exchange putative 3h+–ca2+ antiporter pro-fission protein drp1 ca2+-induced permeability transition atp-dependent ca2+ uptake hypoxic-ischemic brain injury pore open-closed probability rr-insensitive release mechanism solute exclusion size ≈ 1500 da 𝛥 𝜇 ˜ ptp open-closed transitions free matrix [ca2+] mitochondrial ptp-activating response ca2+-dependent pore membrane potential-modulated pathway mg2+-prevented ca2+ release forty-kilodalton protein age-related phenotype late embryonic stages mitochondrial unselective channels mitochondrial permeability transition ca2+ ionophore eth129 mitochondrial calcium uniporter permeability transition pore permeability pore transition mitochondrial ca2+ uniporter total mitochondrial ca2+ license information pmcid 3na+–1ca2+ stoichiometry α-ketoglutarate dehydrogenase ca2+-dependent apoptosis rr-insensitive putative allowing matrix [ca2+] calcium-release channel ca2+ release channel selective ca2+ release mediate mitochondrial depolarization

Questions {❓}

• A Ca2+ release channel in Drosophila mitochondria: the missing link between the PTP of yeast and mammals?
• Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore?
• The PTP as a mitochondrial Ca2+ release channel: only a hypothesis?
• The mitochondrial permeability transition pore as a Ca2+ release channel: is lack of selectivity a problem or an advantage?
• Why is then the rate of Ca2+ efflux so slow?

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• https://www.linkedin.com/company/ncbinlm
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