
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter - PubMed
Description:
Mitochondrial Ca(2+) homeostasis has a key role in the regulation of aerobic metabolism and cell survival, but the molecular identity of the Ca(2+) channel, the mitochondrial calcium uniporter, is still unknown. Here we have identified in silico a protein (named MCU) that shares tissue distribution …
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Keywords {🔍}
mitochondrial, calcium, doi, pmid, pmc, protein, mcu, uniporter, pubmed, cell, free, article, nature, metabolism, molecular, channel, uptake, mitochondria, review, channels, epub, articles, cited, mesh, sequence, figure, physiol, nih, gene, main, states, ncbi, abstract, conflict, interest, similar, references, information, resources, jun, membrane, homeostasis, silencing, hela, cells, inositol, lipid, bilayers, physiological, mol,
Topics {✒️}
united states government ip3-sensitive channels hela cells main page content funding linkout ruthenium-red-sensitive mitochondrial ca mitochondrial calcium uniporter sequence includes mitochondria channel calcium planar lipid bilayers aerobic metabolism putative pore-forming region mesh keyword inositol 1 pubchem substance grants mitochondrial ca2+ uniporter mol cell biochem membrane calcium signalling silencing physiol cell physiol articles references szabadkai 5-trisphosphate-generating agonists resources nature 26350567 molecular nature calcium mcu overexpression doubled hhs forty-kilodalton protein protein protein molecular identity molecular basis 40-kda protein identified data demonstrate authors declare extramural research support pubmed central transmembrane domains cellular ca2+ signaling high ca2+ close similar articles cited mitochondrial ca belcher-timme ca shares tissue distribution short interfering rna negatively charged residues signal transduction pathways trends biochem sci medgen nucleotide omim cell survival
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