
DOI . ORG {
}
Title[redir]:
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria | PNAS
Description:
Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death are tightly regulated by the balance between fusion and fission processes. Excessive fragmentation can b...
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Keywords {๐}
mitochondrial, drp, calcineurin, cells, mitochondria, crossref, ara, pubmed, fragmentation, google, scholar, fission, fig, fccp, cell, depolarization, phosphorylation, translocation, protein, cytosolic, dephosphorylation, organelle, data, italy, shape, proteins, membrane, treated, subcellular, morphology, fusion, activity, csa, experiments, min, drpyfp, biol, hela, induced, shown, mutants, national, article, information, view, inhibition, role, institute, regulates, imaging,
Topics {โ๏ธ}
protonophore carbonylcyanide-p-trifluoromethoxy phenylhydrazone org/cgi/content/full/0808249105/dcsupplemental calcein staining/co2+-quenching technique csa analogue n-methylval-4-csa ca2+-free buffers showed social media facebook mn-dependent superoxide dismutase tg-releasable ca2+ peak jan-willem van ittersum supporting information online ca2+-calmodulin dependent fashion vertebrate-specific pฮฒ domain ca2+-dependent phosphatase calcineurin a-kinase anchoring protein ch dulbecco-telethon institute ara [supporting information opa1-dependent cristae remodeling drp1s616-yfp mutants behaved long-lasting mitochondrial depolarization site-specific mutagenesis shows cereghetti dulbecco-telethon institute stangherlin dulbecco-telethon institute drp1s616-yfp mutants displayed real-time imaging confirmed cyclosporin a-sensitive channel sophisticated auditoryโmotor learning link mitochondrial dysfunction steady-state mitochondrial morphology ca2+/calcineurin dependent dephosphorylation martins de brito dynamin i-calcineurin complex dynamin-related protein drp1 authors affiliations current emotional state er ca2+ release calcineurin/drp1-dependent fission sds/page loading buffer drp1-dependent mitochondrial fragmentation intracellular calcium dependence librarian recommend pnas pnas highlights newsletter cyclin dependent kinase cyclin-dependent kinase 5 authors declare cytoplasmic ca2+ rise share promotes mitochondrial fission vertebrate-specific domain intracellular ca2+ levels primary human fibroblasts
Questions {โ}
- How does calcineurin regulate Drp1-dependent mitochondrial fission?
- What is the relative role of S616 and S637 in controlling subcellular localization and function of Drp1?
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