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nature portfolio ionizable cationic lipid/phosphatidylcholine/cholesterol/peg-lipid ionizable cationic lipid/phosphatidylcholine/cholesterol/peg/lipid lipid-varied libraries 5a2-sc8-based dendrimer lnps ss-cleavable proton-activated lipid commercial purification kits ss-cleavable ph-activated lipid privacy policy avoid graft-versus-host reactions recombinant alpha1-antitrypsin fc-fused advertising bnt162b2-immunized sars-cov-1 survivors nod-prkdcscid-il2rγ null mice exon-skipping tricyclo-dna oligomers cationic phema-g-pdmaema polymers methylmalonyl-coa mutase activity crispr-cas gene editing anti-sars-cov-2 antibody mrna-bnt162b2 sars-cov-2 vaccine mrna vaccine-induced neoantigen-specific trivalent nucleoside-modified mrna dlin-mc3-dma-based formulations anti-ctla-4 monoclonal antibody pan-sarbecovirus neutralizing antibodies reprints crispr/cas nuclease system redox-responsive polymer pdsa respiratory syncytial virus 143 dotap/chol/dspe-polyethylene glycol anti-sars-cov-2 antibodies charge-neutralizing intramolecular rearrangement tumor-mrna-transfected dendritic cells open reading frame full-length wild-type regional multidrug-resistant bacterial sepsis sars-cov-2 omicron variant crispr/cas-based methods schumann adopted peg[glu sars-cov-2 exposure history high-efficacy disease-modifying therapies anti-inflammatory cytokine il-10 west china hospital homology-driven genome editing polymer–lipid hybrid nanoparticles factor viii-encoding mrna robust t-cell response recombinant receptor-binding domain αpv1 antibody-encapsulated mrna

Questions {❓}

• (1) How can mRNA macromolecules be better delivered?
• CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?
• Determinants and implications of mRNA poly(A) tail size–does this protein make my tail look big?
• Will SARS-CoV-2 variants of concern affect the promise of vaccines?
• MRNA: a novel avenue to antibody therapy?

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      email:[email protected]
PostalAddress:
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
      name:Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, USA
      name:Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China

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