
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells - PMC
Description:
Cytotoxic T lymphocytes (CTLs) modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies are effective in preclinical models and are being tested in several clinical trials. Although CTLs bearing stably ...
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Keywords {🔍}
cells, car, doi, rna, expression, pubmed, google, scholar, cars, ctls, pmc, mrna, target, article, cell, human, leukemia, mice, free, injection, disease, data, fig, antigen, blood, survival, nalm, day, vitro, electroporation, model, tcell, days, gene, lymphocytes, transfection, time, control, chimeric, lentiviral, therapy, kcd, expressed, potential, activity, surface, mesothelin, stably, vivo, efficacy,
Topics {✒️}
leukemia-related hind-limb paralysis therapy-induced b-cell deficiency hacein-bey-abina author disclosure statement cellular immune-mediated pathways including stem-cell transplant /sec/cm2/sr represents mice efficient t-cell receptor anterior–posterior prone position true cost-effectiveness plays pmc beta search mrna dose-dependent ifn-γ flow-cytometric ctl assay provide t-cell activation anti-cd20 monoclonal antibody graft-versus-leukemia reactions cell-therapy products advancing chimeric antigen receptor-modified fluorescently-conjugated monoclonal antibodies flow-based ctl assay improve t-cell persistence flow-cytometric cytotoxicity assay chimeric antigen receptor-redirected total photon flux±se fluorescein isothiocyanate–anti-cd8 coexpress tumor-specific receptors 150 mg/kg d-luciferin tumor-specific t-bodies pe-labeled anti-cd107a ab rnase-free water pathogen-free conditions nod/scid/γc–/– null graft-versus-host disease graft-versus-leukemia effect single-chain variable fragment engineered human tmpk/azt cd19-negative precursor population target-based cytotoxic properties human t-lymphocyte cytotoxicity car t-cell proliferation normal b-cell pool including long-term expression firefly luciferase-positive leukemia ifn-γ secretion titrates mesothelin-directed car ctls retrovirus-mediated gene therapy cd19-directed rna car+ antigen-specific cd107a expression anti-cd19-bbz car mrna-transfected car+ ctls
Questions {❓}
- Do CARs need a driver's license?
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