
LINK . SPRINGER . COM {
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Title:
Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia | Journal of Hematology & Oncology
Description:
In a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2 weeks after the second dose was significantly lower in the ten patients with myelofibrosis compared to the 32 with essential thrombocythemia (nโ=โ17) and polycythemia vera (nโ=โ15) grouped together, both in terms of neutralizing anti-SARS-CoV-2 IgG titers and seroprotection rates (32.47 AU/mL vs 217.97 AU/mL, pโ=โ0.003 and 60% vs 93.8%, pโ=โ0.021, respectively). Ruxolitinib, which was the ongoing treatment in five patients with myelofibrosis and three with polycythemia vera, may be implicated in reducing vaccine immunogenicity (pโ=โ0.076), though large prospective study is needed to address this issue.
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Keywords {๐}
patients, myelofibrosis, article, vaccine, study, ruxolitinib, data, response, covid, institute, myeloproliferative, irccs, elena, cancer, rome, italy, bntb, clinical, essential, vera, igg, mpn, range, google, scholar, regina, national, research, polycythemia, thrombocythemia, dose, vaccination, table, neoplasms, pubmed, direction, privacy, cookies, journal, lower, compared, access, published, number, manuscript, marchesi, treatment, antisarscov, weeks, median,
Topics {โ๏ธ}
/en/immunodiagnostic-solutions/clinical-areas/infectious-diseases/covid-19 anti-sars-cov-2 igg titers identifies s1/s2-neutralizing igg anti-sars-cov-2 bnt162b2 vaccine simona di martino ornella di bella previous sars-cov-2 infection polyfunctional t-cell responses sars-cov-2 infection antonia la malfa immonogenicity data post-vaccination san gallicano institute neutralizing antibody titers bnt162b2 mrna vaccine privacy choices/manage cookies article download pdf t-cell exhaustion previous covid-19 infection valentina laquintana fabrizio ensoli branka vujovic igg titer monitoring full size table creative commons licence signed informed consents nk-cell dysfunction develop severe covid-19 good clinical practice european economic area detrimental effect exerted high mortality rate shared inflammatory pathways allocated human resources obtain permission directly conditions privacy policy case seriesโ selection maintaining social distancing janus kinase inhibitors additional information publisher' scientific direction mrna vaccine fragile patients including essential thrombocythemia letter large prospective study journal finder publish medical direction accepting optional cookies myeloproliferative neoplasms covid-19 patients semiquantitatively gianluca falzone
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headline:Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia
description:In a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2ย weeks after the second dose was significantly lower in the ten patients with myelofibrosis compared to the 32 with essential thrombocythemia (nโ=โ17) and polycythemia vera (nโ=โ15) grouped together, both in terms of neutralizing anti-SARS-CoV-2 IgG titers and seroprotection rates (32.47ย AU/mL vs 217.97ย AU/mL, pโ=โ0.003 and 60% vs 93.8%, pโ=โ0.021, respectively). Ruxolitinib, which was the ongoing treatment in five patients with myelofibrosis and three with polycythemia vera, may be implicated in reducing vaccine immunogenicity (pโ=โ0.076), though large prospective study is needed to address this issue.
datePublished:2021-07-29T00:00:00Z
dateModified:2021-07-29T00:00:00Z
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mRNA vaccine
COVID-19
Ph negative myeloproliferative neoplasms
Oncology
Hematology
Cancer Research
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headline:Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia
description:In a population of 42 Philadelphia negative myeloproliferative neoplasm patients, all on systemic active treatment, the likelihood of responding to anti-SARS-CoV-2 BNT162b2 vaccine at 2ย weeks after the second dose was significantly lower in the ten patients with myelofibrosis compared to the 32 with essential thrombocythemia (nโ=โ17) and polycythemia vera (nโ=โ15) grouped together, both in terms of neutralizing anti-SARS-CoV-2 IgG titers and seroprotection rates (32.47ย AU/mL vs 217.97ย AU/mL, pโ=โ0.003 and 60% vs 93.8%, pโ=โ0.021, respectively). Ruxolitinib, which was the ongoing treatment in five patients with myelofibrosis and three with polycythemia vera, may be implicated in reducing vaccine immunogenicity (pโ=โ0.076), though large prospective study is needed to address this issue.
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name:Microbiology and Virology Unit, Dermatological Clinical and Research Department, IRCCS San Gallicano Institute, Rome, Italy
name:Medical Direction, IRCCS Regina Elena National Cancer Institute and San Gallicano Institute, Rome, Italy
name:Hematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy
name:Microbiology and Virology Unit, Dermatological Clinical and Research Department, IRCCS San Gallicano Institute, Rome, Italy
name:Medical Direction, IRCCS Regina Elena National Cancer Institute and San Gallicano Institute, Rome, Italy
name:Scientific Direction, IRCCS San Gallicano Institute, Rome, Italy
name:Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy
name:Hematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy
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