We are analyzing https://link.springer.com/article/10.1186/s12943-020-01286-3.

Title:
Circular RNA: metabolism, functions and interactions with proteins | Molecular Cancer
Description:
Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs.
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Keywords {🔍}

pubmed, article, google, scholar, cas, circrnas, rna, circular, central, circrna, proteins, cell, cancer, protein, mol, rnas, yang, wang, nuclear, translation, liu, mrna, binding, interactions, promotes, zhang, cells, chen, functions, circrnaprotein, transcription, interaction, complex, progression, biogenesis, studies, study, nat, dna, splicing, factor, inhibits, ternary, metabolism, zhou, regulation, complexes, expression, directly, translocation,

Topics {✒️}

rui-hua xu profile circrnas located huai-qiang ju c-terminal lysine-rich domain circular rna circ-ccnb1 de-shen wang circrna-protein-mrna ternary complexes augmenting beta-catenin signaling article download pdf circrna-protein-nucleic acid high-throughput rna-sequencing circ-gli1 promotes metastasis full-length protein counterparts testis-determining gene sry represses pgc-1α mediated poly-adenosine tail adding hundred-fold higher productivity aggravates doxorubicin-induced cardiomyopathy highly base-paired rod auroraa/nf-kappab pathway zinc finger protein mammalian-wide interspersed repeats modulating ctnnbip1-dependent activation wnt/beta-catenin pathway enables mitochondria-targeted therapy circular rna cirs-7/cdr1as circular rna cdr1as/cirs-7 hectd1/zc3h12a-dependent ubiquitination circular rna-protein interactions triple-negative breast cancer oncoprotein-encoding circular rna structure-dependent mechanism mediated imperfect base-paired regions pro−/anti-angiogenic isoforms acc1 pre-mrna shifts wnt/beta-catenin pathways protein-coding genes shifts amp-activated protein kinase real-timecircrna-protein interactions m6a-dependent manner mediated dsrna-activated protein kinase pre-mrna undergoes splicing small circular rna receptor subunit il-13rα1 pre-mrna processing machinery sponging mir-514a-5p verified circrna-protein interactions increases central sensitization anti-senescence proteins inhibitor structure-mediated rna decay

Questions {❓}

, metabolites and ionic compounds) that combine with circRNPs?
, the matrix and adjacent or distant cells)?
For example, what factors determine whether circRNAs act as scaffolds or decoys to support or impede proteins?
However, this study did not decipher how these molecules combine with each other (through binding domain, dynamic structure or sequence recognition?
RIP, RNA pull-down, RNA-sequencing) in view of the low abundance and special structure of circRNAs?

Schema {🗺️}

WebPage:
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         headline:Circular RNA: metabolism, functions and interactions with proteins
         description:Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs.
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      headline:Circular RNA: metabolism, functions and interactions with proteins
      description:Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs.
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         CircRNA
         CircRNA-protein interaction
         Mechanism
         Metabolism
         Function
         Cancer Research
         Oncology
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      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, P. R. China
      name:State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China
      name:Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, P. R. China

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