We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-6481-9_5.

Title:
RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines | SpringerLink
Description:
Developing effective mRNA vaccines poses certain challenges concerning mRNA stability and ability to induce sufficient immune stimulation and requires a specific panel of techniques for production and testing. Here, we describe the production of stabilized mRNA with...
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines
      pageEnd:107
      pageStart:89
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-6481-9.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:RNA Vaccines
         isbn:
            978-1-4939-6481-9
            978-1-4939-6479-6
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Susanne Rauch
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Johannes Lutz
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aleksandra Kowalczyk
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Schlake
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Regina Heidenreich
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:mRNA vaccines, RNActive®, Protamine complexation, GC enrichment, Adjuvanticity, Stabilized mRNA
      description:Developing effective mRNA vaccines poses certain challenges concerning mRNA stability and ability to induce sufficient immune stimulation and requires a specific panel of techniques for production and testing. Here, we describe the production of stabilized mRNA with enhanced immunogenicity, generated using conventional nucleotides only, by introducing changes to the mRNA sequence and by complexation with the nucleotide-binding peptide protamine (RNActive® technology). Methods described here include the synthesis, purification, and protamine complexation of mRNA vaccines as well as a comprehensive panel of in vitro and in vivo methods for evaluation of vaccine quality and immunogenicity.
      datePublished:2017
      isAccessibleForFree:
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Book:
      name:RNA Vaccines
      isbn:
         978-1-4939-6481-9
         978-1-4939-6479-6
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:CureVac AG
      address:
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      address:
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         type:PostalAddress
      name:CureVac AG
      address:
         name:CureVac AG, Tübingen, Germany
         type:PostalAddress
      name:CureVac AG
      address:
         name:CureVac AG, Tübingen, Germany
         type:PostalAddress
      name:CureVac AG
      address:
         name:CureVac AG, Tübingen, Germany
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Susanne Rauch
      affiliation:
            name:CureVac AG
            address:
               name:CureVac AG, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Johannes Lutz
      affiliation:
            name:CureVac AG
            address:
               name:CureVac AG, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Aleksandra Kowalczyk
      affiliation:
            name:CureVac AG
            address:
               name:CureVac AG, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Thomas Schlake
      affiliation:
            name:CureVac AG
            address:
               name:CureVac AG, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Regina Heidenreich
      affiliation:
            name:CureVac AG
            address:
               name:CureVac AG, Tübingen, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:CureVac AG, Tübingen, Germany
      name:CureVac AG, Tübingen, Germany
      name:CureVac AG, Tübingen, Germany
      name:CureVac AG, Tübingen, Germany
      name:CureVac AG, Tübingen, Germany
WebPageElement:
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