
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia - PMC
Description:
Cytotoxic T lymphocytes modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies have demonstrated activity in early phase clinical trials. While T cells bearing stably expressed CARs are efficacious and ...
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Keywords {🔍}
cells, car, doi, rna, leukemia, pubmed, google, scholar, article, pmc, disease, cars, mice, ctx, free, days, tcell, dose, mrna, survival, day, infusions, cell, model, fig, efficacy, infusion, expression, single, blood, antigen, multiple, schedule, luciferase, chimeric, stably, human, bbz, time, control, data, clinical, injection, longterm, models, primary, modified, transfection, animals, effect,
Topics {✒️}
restriction-enzyme-digested pcr products author disclosure statement mock-transduced t-cell controls xenogeneic graft-versus-host disease t-cell multi-infusion strategy pmc beta search jaw/tooth root site mrna-engineered anti-cd19 car chimeric antigen receptor-modified meso–41bbz-treated mice surviving repeat t-cell infusions provide t-cell activation t-cell homeostatic proliferation red t-cell signal viability post-transfection ranged t-cell infusions versus jaw/tooth harbor site combine antibody-based specificity graft-versus-leukemia reactions slow t-cell proliferation graft-versus-host disease coexpress tumor-specific receptors control versus meso–41bbz anterior–posterior prone position anti-gd2 antibody therapy car t-cell trials photons/sec/cm2/steradian rnase-free water pathogen-free conditions cd20-specific adoptive immunotherapy 150 mg/kg d-luciferin human t-lymphocyte cytotoxicity bone marrow transplantation anti-cd19 rna car human cd19-targeted effector anti-cd19 rna cars tooth root site short-term expression platform measured multi-infusion approach 60 mg/kg ip×1 24 hr chimeric antigen receptor potential long-term persistence cd19-directed rna car short-term activation liposome-mediated transfection t-cell receptors acute lymphoblastic leukemia t-cell manufacture t-cell population anti-cd19 cars previously
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