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We are analyzing https://link.springer.com/article/10.1186/s40425-019-0520-5.

Title:
Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer | Journal for ImmunoTherapy of Cancer
Description:
Background Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses. Methods We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy. Patients were stratified into three strata (1: non-squamous NSCLC, no epidermal growth factor receptor (EGFR) mutation, PR/SD after ≥4 cycles of platinum- and pemetrexed-based treatment [n = 16]; 2: squamous NSCLC, PR/SD after ≥4 cycles of platinum-based and non-platinum compound treatment [n = 8]; 3: non-squamous NSCLC, EGFR mutation, PR/SD after ≥3 and ≤ 6 months EGFR-tyrosine kinase inhibitor (TKI) treatment [n = 2]). Patients received intradermal BI1361849, local radiation (4 × 5 Gy), then BI1361849 until disease progression. Strata 1 and 3 also had maintenance pemetrexed or continued EGFR-TKI therapy, respectively. The primary endpoint was evaluation of safety; secondary objectives included assessment of clinical efficacy (every 6 weeks during treatment) and of immune response (on Days 1 [baseline], 19 and 61). Results Study treatment was well tolerated; injection site reactions and flu-like symptoms were the most common BI1361849-related adverse events. Three patients had grade 3 BI1361849-related adverse events (fatigue, pyrexia); there was one grade 3 radiation-related event (dysphagia). In comparison to baseline, immunomonitoring revealed increased BI1361849 antigen-specific immune responses in the majority of patients (84%), whereby antigen-specific antibody levels were increased in 80% and functional T cells in 40% of patients, and involvement of multiple antigen specificities was evident in 52% of patients. One patient had a partial response in combination with pemetrexed maintenance, and 46.2% achieved stable disease as best overall response. Best overall response was SD in 57.7% for target lesions. Conclusion The results support further investigation of mRNA-based immunotherapy in NSCLC including combinations with immune checkpoint inhibitors. Trial registration ClinicalTrials.gov identifier: NCT01915524 .
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
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Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

WebPage:
      mainEntity:
         headline:Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
         description:Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses. We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy. Patients were stratified into three strata (1: non-squamous NSCLC, no epidermal growth factor receptor (EGFR) mutation, PR/SD after ≥4 cycles of platinum- and pemetrexed-based treatment [n = 16]; 2: squamous NSCLC, PR/SD after ≥4 cycles of platinum-based and non-platinum compound treatment [n = 8]; 3: non-squamous NSCLC, EGFR mutation, PR/SD after ≥3 and ≤ 6 months EGFR-tyrosine kinase inhibitor (TKI) treatment [n = 2]). Patients received intradermal BI1361849, local radiation (4 × 5 Gy), then BI1361849 until disease progression. Strata 1 and 3 also had maintenance pemetrexed or continued EGFR-TKI therapy, respectively. The primary endpoint was evaluation of safety; secondary objectives included assessment of clinical efficacy (every 6 weeks during treatment) and of immune response (on Days 1 [baseline], 19 and 61). Study treatment was well tolerated; injection site reactions and flu-like symptoms were the most common BI1361849-related adverse events. Three patients had grade 3 BI1361849-related adverse events (fatigue, pyrexia); there was one grade 3 radiation-related event (dysphagia). In comparison to baseline, immunomonitoring revealed increased BI1361849 antigen-specific immune responses in the majority of patients (84%), whereby antigen-specific antibody levels were increased in 80% and functional T cells in 40% of patients, and involvement of multiple antigen specificities was evident in 52% of patients. One patient had a partial response in combination with pemetrexed maintenance, and 46.2% achieved stable disease as best overall response. Best overall response was SD in 57.7% for target lesions. The results support further investigation of mRNA-based immunotherapy in NSCLC including combinations with immune checkpoint inhibitors. ClinicalTrials.gov identifier: NCT01915524 .
         datePublished:2019-02-08T00:00:00Z
         dateModified:2019-02-08T00:00:00Z
         pageStart:1
         pageEnd:14
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s40425-019-0520-5
         keywords:
            Clinical trial
            Hypofractionated radiotherapy
            Immunomonitoring
            mRNA active cancer immunotherapy
            Non-small cell lung cancer
            BI1361849
            CV9202
            Oncology
            Immunology
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            volumeNumber:7
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               name:Martin Früh
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                        name:Hospital of St Gallen, St Gallen and University of Bern, Bern, Switzerland
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ScholarlyArticle:
      headline:Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
      description:Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses. We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy. Patients were stratified into three strata (1: non-squamous NSCLC, no epidermal growth factor receptor (EGFR) mutation, PR/SD after ≥4 cycles of platinum- and pemetrexed-based treatment [n = 16]; 2: squamous NSCLC, PR/SD after ≥4 cycles of platinum-based and non-platinum compound treatment [n = 8]; 3: non-squamous NSCLC, EGFR mutation, PR/SD after ≥3 and ≤ 6 months EGFR-tyrosine kinase inhibitor (TKI) treatment [n = 2]). Patients received intradermal BI1361849, local radiation (4 × 5 Gy), then BI1361849 until disease progression. Strata 1 and 3 also had maintenance pemetrexed or continued EGFR-TKI therapy, respectively. The primary endpoint was evaluation of safety; secondary objectives included assessment of clinical efficacy (every 6 weeks during treatment) and of immune response (on Days 1 [baseline], 19 and 61). Study treatment was well tolerated; injection site reactions and flu-like symptoms were the most common BI1361849-related adverse events. Three patients had grade 3 BI1361849-related adverse events (fatigue, pyrexia); there was one grade 3 radiation-related event (dysphagia). In comparison to baseline, immunomonitoring revealed increased BI1361849 antigen-specific immune responses in the majority of patients (84%), whereby antigen-specific antibody levels were increased in 80% and functional T cells in 40% of patients, and involvement of multiple antigen specificities was evident in 52% of patients. One patient had a partial response in combination with pemetrexed maintenance, and 46.2% achieved stable disease as best overall response. Best overall response was SD in 57.7% for target lesions. The results support further investigation of mRNA-based immunotherapy in NSCLC including combinations with immune checkpoint inhibitors. ClinicalTrials.gov identifier: NCT01915524 .
      datePublished:2019-02-08T00:00:00Z
      dateModified:2019-02-08T00:00:00Z
      pageStart:1
      pageEnd:14
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s40425-019-0520-5
      keywords:
         Clinical trial
         Hypofractionated radiotherapy
         Immunomonitoring
         mRNA active cancer immunotherapy
         Non-small cell lung cancer
         BI1361849
         CV9202
         Oncology
         Immunology
      image:
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      isPartOf:
         name:Journal for ImmunoTherapy of Cancer
         issn:
            2051-1426
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Alexandros Papachristofilou
            affiliation:
                  name:University Hospital Basel
                  address:
                     name:Clinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Madeleine M. Hipp
            affiliation:
                  name:CureVac AG
                  address:
                     name:CureVac AG, Tübingen, Germany
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            name:Ute Klinkhardt
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            name:Martin Früh
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                  name:Hospital of St Gallen, St Gallen and University of Bern
                  address:
                     name:Hospital of St Gallen, St Gallen and University of Bern, Bern, Switzerland
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            name:Martin Sebastian
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                  name:University Hospital Frankfurt
                  address:
                     name:University Hospital Frankfurt, Frankfurt, Germany
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            type:Person
            name:Christian Weiss
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                  name:University Hospital Frankfurt
                  address:
                     name:University Hospital Frankfurt, Frankfurt, Germany
                     type:PostalAddress
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            type:Person
            name:Miklos Pless
            affiliation:
                  name:Cantonal Hospital of Winterthur
                  address:
                     name:Cantonal Hospital of Winterthur, Winterthur, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard Cathomas
            affiliation:
                  name:Hospital Graubünden
                  address:
                     name:Hospital Graubünden, Chur, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wolfgang Hilbe
            affiliation:
                  name:Wilhelminenspital
                  address:
                     name:Medical Department, Center for Oncology and Hematology, Wilhelminenspital, Wien, Austria
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                  address:
                     name:Department of Internal Medicine III, University Medical Center Mainz, Mainz, Germany
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            name:Jürgen Alt
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                  name:University Medical Center Mainz
                  address:
                     name:Department of Internal Medicine III, University Medical Center Mainz, Mainz, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Helge Bischoff
            affiliation:
                  name:Thoraxklinik Heidelberg gGmbH
                  address:
                     name:Thoraxklinik Heidelberg gGmbH, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Geißler
            affiliation:
                  name:Klinik für Allg Innere Medizin, Onkolologie/ Hämatologie, Gastroenterologie, Infektiologie
                  address:
                     name:Klinik für Allg Innere Medizin, Onkolologie/ Hämatologie, Gastroenterologie, Infektiologie, Esslingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Frank Griesinger
            affiliation:
                  name:Pius Hospital University
                  address:
                     name:Department Hematology and Oncology, Pius Hospital University, Oldenburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Medical Campus University of Oldenburg
                  address:
                     name:Department Internal Medicine-Oncology, Medical Campus University of Oldenburg, Oldenburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Karl-Josef Kallen
            affiliation:
                  name:eTheRNA Immunotherapies NV
                  address:
                     name:eTheRNA Immunotherapies NV, Niel, Belgium
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