
NCBI . NLM . NIH . GOV {
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Title[redir]:
Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals - PMC
Description:
Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe means for protein therapies. While recent findings highlight the enormous therapeutic potential of mRNA, evidence that mRNA-based protein therapies are ...
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Keywords {🔍}
mrna, epo, protein, unmodified, doi, mice, pubmed, google, scholar, figure, expression, levels, rna, engineered, sequenceengineered, cells, pmc, animals, responses, blood, physiological, mouse, treatment, pseudouridine, supplementary, reticulocyte, article, erythropoietin, dose, modified, modifications, effects, administration, transitcomplexed, vivo, analyzed, free, injection, mrnas, nucleosidemodified, data, hours, nucleoside, pigs, hematocrit, serum, open, received, therapies, therapeutic,
Topics {✒️}
ionizable cationic lipid/phosphatidylcholine/cholesterol/peg-lipid rig-i-mediated antiviral responses transit-complexed sequence-engineered mrna anti-epo immune responses applying sequence-engineered molecules accomplished employing sequence-optimized pmc beta search anti-epo antibody generation developing mrna-vaccine technologies mepo-encoding mrna elicited epo-specific antibody responses transit-complexed epo mrna potent antigen-presenting cells basic luciferase-encoding mrna le genest-saint-isle sequence-engineered epo mrna enzyme-linked immunosorbent assay mrna-based protein therapies messenger rna-based vaccines manufacturing nucleoside-modified mrna immunostimulating single-stranded rna sysmex xt-2000iv mrna-based protein therapy intraperitoneally injected transit-complexes harbored chemically-modified nucleosides sequence-engineered mrna coding sequence-engineered nucleic acids induces vascular regeneration exogenous ligand-based mechanisms sequence-engineered mrna outperformed protein-specific antibody response unmodified mrna elicits weight-adjusted dose similar produced nucleoside-modified counterparts mouse epo protein erythropoietin-encoding mrna found epo mrna elicit hepatic gene silencing sequence-engineered mrnas harbored high luciferase activity mouse epo levels vasopressin-deficient rats provided goat anti-mouse long-term/continued treatment porcine epo levels antigen-encoding mrna innate antiviral responses anti-epo-antibody anti-epo antibody sirna lipid nanoparticles
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