DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06650-9, but it redirected us to https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06650-9. The analysis below is for the second page.

Title[redir]:
LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling | Journal of Translational Medicine | Full Text
Description:
Background High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and chemoresistance. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. This study investigates the role of the cytoplasmic lncRNA LINC02888 in HGSOC. Methods We identified overexpression of LINC02888 in HGSOC tissues and cell lines through whole-transcriptome sequencing, qPCR, in situ hybridization, and analyses of TCGA/GTEx datasets. Functional assays including CCK-8, EdU, colony formation, wound healing, Transwell migration/invasion, and flow cytometry were performed after modulating LINC02888 expression. RNA pull-down coupled with mass spectrometry identified the RNA-binding protein PPIB as an interactor of LINC02888. RNA-seq following both LINC02888 and PPIB knockdown, along with Western blot, qPCR analyses and functional assays, revealed that LAPTM5 is a downstream effector. Furthermore, RIP-qPCR, deletion mapping, and ActD assays confirmed that LINC02888 binds PPIB, which stabilizes LAPTM5 mRNA via its 3’UTR. The effect on the RIG-I–like receptor pathway was evaluated by measuring the expression levels of RIG-I, IRF7, and ISG15. Finally, in vivo, the critical role of the LINC02888/PPIB/ LAPTM5 axis in ovarian tumor progression were explored by axillary subcutaneous injection of specifically transfected OVCAR3 cells into nude mice. Results LINC02888 was significantly upregulated in HGSOC tissues and correlated with advanced disease and poor prognosis. Silencing LINC02888 inhibited proliferation, migration, and invasion, while inducing apoptosis; conversely, overexpression promoted these oncogenic behaviors. Mechanistically, LINC02888 interacts with PPIB to stabilize LAPTM5 mRNA via its 3’UTR, resulting in elevated LAPTM5 protein levels and suppression of RIG-I–like receptor signaling. Rescue experiments confirmed the critical role of the LINC02888–PPIB–LAPTM5 axis in HGSOC progression in vivo and vitro. Conclusions Our findings reveal that LINC02888 drives HGSOC progression through a mechanism involving PPIB-mediated stabilization of LAPTM5 mRNA, which suppresses RIG-I–like receptor signaling. It also appropriately suggests that inhibiting this innate immune pathway may contribute to an immunosuppressive tumor microenvironment, making the LINC02888–PPIB–LAPTM5 axis a promising therapeutic target for this aggressive malignancy. Graphical Abstract

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 75,529,999 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

linc, cells, ppib, laptm, hgsoc, cell, fig, pubmed, skov, ovcar, rna, overexpression, article, knockdown, mrna, google, scholar, expression, ovarian, anglne, analysis, cancer, assays, assay, central, cas, receptor, rigilike, usa, protein, data, qpcr, pathway, proliferation, experiments, scale, significantly, bar, immune, lncrnas, size, tumor, china, lncrna, migration, performed, min, revealed, levels, binding,

Topics {✒️}

gov/ccg/research/genome-sequencing/tcga mir-489-3p/dnmt3a signaling axis lncrna-mediated post-transcriptional regulation 5–15% sds-page gels a20-mediated nlrp3 deubiquitination tlr4-induced ros signaling biology-driven therapy advances glucose-induced linc01419 reprograms additional information publisher' wwp2-pten-akt pathway hormone-responsive breast cancer regulate e-cadherin expression full size image biotin-labeled linc02888 probe sars-cov-2 infection human rna-binding proteins anti-flag antibody detected normal ovarian tissue paraffin-embedded tissue sections anti-dig-biotin antibody full-length laptm5 transcript epithelial ovarian cancer receptor pathway-related proteins linc02888-driven hgsoc progression tumor-inhibitory effects induced resulting double-stranded cdna streptavidin-coated magnetic beads privacy choices/manage cookies additional plasmid constructs regulate pre-mrna splicing biotin-labeled probes agarose gel electrophoresis patient-derived xenografts linc02888/ppib/ laptm5 axis linc02888–ppib–laptm5 axis linc02888/ppib/laptm5 axis linc02888-ppib-laptm5 axis si-ppib significantly reduced ovarian tissue samples dig‐labeled linc02888 probe high-glucose dmem host-matched control igg xenograft models support chemiluminescence imaging system laptm5 mediates immature bmc ovarian tumor progression standard culture conditions larger tumor size rna-binding protein ppib

Schema {🗺️}

WebPage:
      mainEntity:
         headline:LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling
         description:High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and chemoresistance. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. This study investigates the role of the cytoplasmic lncRNA LINC02888 in HGSOC. We identified overexpression of LINC02888 in HGSOC tissues and cell lines through whole-transcriptome sequencing, qPCR, in situ hybridization, and analyses of TCGA/GTEx datasets. Functional assays including CCK-8, EdU, colony formation, wound healing, Transwell migration/invasion, and flow cytometry were performed after modulating LINC02888 expression. RNA pull-down coupled with mass spectrometry identified the RNA-binding protein PPIB as an interactor of LINC02888. RNA-seq following both LINC02888 and PPIB knockdown, along with Western blot, qPCR analyses and functional assays, revealed that LAPTM5 is a downstream effector. Furthermore, RIP-qPCR, deletion mapping, and ActD assays confirmed that LINC02888 binds PPIB, which stabilizes LAPTM5 mRNA via its 3’UTR. The effect on the RIG-I–like receptor pathway was evaluated by measuring the expression levels of RIG-I, IRF7, and ISG15. Finally, in vivo, the critical role of the LINC02888/PPIB/ LAPTM5 axis in ovarian tumor progression were explored by axillary subcutaneous injection of specifically transfected OVCAR3 cells into nude mice. LINC02888 was significantly upregulated in HGSOC tissues and correlated with advanced disease and poor prognosis. Silencing LINC02888 inhibited proliferation, migration, and invasion, while inducing apoptosis; conversely, overexpression promoted these oncogenic behaviors. Mechanistically, LINC02888 interacts with PPIB to stabilize LAPTM5 mRNA via its 3’UTR, resulting in elevated LAPTM5 protein levels and suppression of RIG-I–like receptor signaling. Rescue experiments confirmed the critical role of the LINC02888–PPIB–LAPTM5 axis in HGSOC progression in vivo and vitro. Our findings reveal that LINC02888 drives HGSOC progression through a mechanism involving PPIB-mediated stabilization of LAPTM5 mRNA, which suppresses RIG-I–like receptor signaling. It also appropriately suggests that inhibiting this innate immune pathway may contribute to an immunosuppressive tumor microenvironment, making the LINC02888–PPIB–LAPTM5 axis a promising therapeutic target for this aggressive malignancy.
         datePublished:2025-06-11T00:00:00Z
         dateModified:2025-06-11T00:00:00Z
         pageStart:1
         pageEnd:25
         license:http://creativecommons.org/licenses/by-nc-nd/4.0/
         sameAs:https://doi.org/10.1186/s12967-025-06650-9
         keywords:
            LINC02888
            PPIB
            LAPTM5
            RIG-I-like receptor pathway
            Immune evasion
            Biomedicine
            general
            Medicine/Public Health
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Figa_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig8_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig9_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig10_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig11_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig12_HTML.png
         isPartOf:
            name:Journal of Translational Medicine
            issn:
               1479-5876
            volumeNumber:23
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:BingJie Rui
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:YanFeng Yang
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:DanBo Geng
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:ZiTeng Kuang
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:TianLi Mu
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:YuXi Liu
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bo Ren
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:RunZe He
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:XiaoWei Zhang
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:YuCi Zhang
               affiliation:
                     name:The University of British Columbia
                     address:
                        name:Department of Computer, The University of British Columbia, Vancouver, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Min Wang
               affiliation:
                     name:Shengjing Hospital of China Medical University
                     address:
                        name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling
      description:High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and chemoresistance. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. This study investigates the role of the cytoplasmic lncRNA LINC02888 in HGSOC. We identified overexpression of LINC02888 in HGSOC tissues and cell lines through whole-transcriptome sequencing, qPCR, in situ hybridization, and analyses of TCGA/GTEx datasets. Functional assays including CCK-8, EdU, colony formation, wound healing, Transwell migration/invasion, and flow cytometry were performed after modulating LINC02888 expression. RNA pull-down coupled with mass spectrometry identified the RNA-binding protein PPIB as an interactor of LINC02888. RNA-seq following both LINC02888 and PPIB knockdown, along with Western blot, qPCR analyses and functional assays, revealed that LAPTM5 is a downstream effector. Furthermore, RIP-qPCR, deletion mapping, and ActD assays confirmed that LINC02888 binds PPIB, which stabilizes LAPTM5 mRNA via its 3’UTR. The effect on the RIG-I–like receptor pathway was evaluated by measuring the expression levels of RIG-I, IRF7, and ISG15. Finally, in vivo, the critical role of the LINC02888/PPIB/ LAPTM5 axis in ovarian tumor progression were explored by axillary subcutaneous injection of specifically transfected OVCAR3 cells into nude mice. LINC02888 was significantly upregulated in HGSOC tissues and correlated with advanced disease and poor prognosis. Silencing LINC02888 inhibited proliferation, migration, and invasion, while inducing apoptosis; conversely, overexpression promoted these oncogenic behaviors. Mechanistically, LINC02888 interacts with PPIB to stabilize LAPTM5 mRNA via its 3’UTR, resulting in elevated LAPTM5 protein levels and suppression of RIG-I–like receptor signaling. Rescue experiments confirmed the critical role of the LINC02888–PPIB–LAPTM5 axis in HGSOC progression in vivo and vitro. Our findings reveal that LINC02888 drives HGSOC progression through a mechanism involving PPIB-mediated stabilization of LAPTM5 mRNA, which suppresses RIG-I–like receptor signaling. It also appropriately suggests that inhibiting this innate immune pathway may contribute to an immunosuppressive tumor microenvironment, making the LINC02888–PPIB–LAPTM5 axis a promising therapeutic target for this aggressive malignancy.
      datePublished:2025-06-11T00:00:00Z
      dateModified:2025-06-11T00:00:00Z
      pageStart:1
      pageEnd:25
      license:http://creativecommons.org/licenses/by-nc-nd/4.0/
      sameAs:https://doi.org/10.1186/s12967-025-06650-9
      keywords:
         LINC02888
         PPIB
         LAPTM5
         RIG-I-like receptor pathway
         Immune evasion
         Biomedicine
         general
         Medicine/Public Health
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Figa_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig8_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig9_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig10_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig11_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-025-06650-9/MediaObjects/12967_2025_6650_Fig12_HTML.png
      isPartOf:
         name:Journal of Translational Medicine
         issn:
            1479-5876
         volumeNumber:23
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:BingJie Rui
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:YanFeng Yang
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:DanBo Geng
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:ZiTeng Kuang
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:TianLi Mu
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:YuXi Liu
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bo Ren
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:RunZe He
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:XiaoWei Zhang
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:YuCi Zhang
            affiliation:
                  name:The University of British Columbia
                  address:
                     name:Department of Computer, The University of British Columbia, Vancouver, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Min Wang
            affiliation:
                  name:Shengjing Hospital of China Medical University
                  address:
                     name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Translational Medicine
      issn:
         1479-5876
      volumeNumber:23
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
      name:The University of British Columbia
      address:
         name:Department of Computer, The University of British Columbia, Vancouver, Canada
         type:PostalAddress
      name:Shengjing Hospital of China Medical University
      address:
         name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:BingJie Rui
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:YanFeng Yang
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:DanBo Geng
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:ZiTeng Kuang
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:TianLi Mu
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:YuXi Liu
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:Bo Ren
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:RunZe He
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:XiaoWei Zhang
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      name:YuCi Zhang
      affiliation:
            name:The University of British Columbia
            address:
               name:Department of Computer, The University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Min Wang
      affiliation:
            name:Shengjing Hospital of China Medical University
            address:
               name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
      name:Department of Computer, The University of British Columbia, Vancouver, Canada
      name:Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

Social Networks {👍}(2)

External Links {🔗}(362)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

4.81s.