NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC7355334/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC7355334/. The analysis below is for the second page.
Title[redir]:
Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle - PMC
Description:
mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement therapy, cancer immunotherapy, immune cell engineering etc. However, optimization of mRNA molecules and efficient in vivo delivery are quite ...
Title[redir]:
Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle - PMC
Description:
mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement therapy, cancer immunotherapy, immune cell engineering etc. However, optimization of mRNA molecules and efficient in vivo delivery are quite ...
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Keywords {🔍}
mrna, doi, delivery, expression, ilpmrna, vivo, sirna, protein, epo, google, scholar, pubmed, lipid, fig, cells, data, pmc, efficiency, ilp, nucleic, mice, ilnp, article, acid, luciferase, free, vitro, liver, fau, imaging, cell, huh, solution, injection, ionizable, nanoparticle, zhang, optimization, mgkg, transfected, time, ilpomepo, lipids, pbs, pka, analysis, collected, ilpmluc, therapeutic, hepatocytes,
Topics {✒️}
dlin-mc3-dma-based sirna liposome adding anti-reverse-cap analog granulocyte-macrophage colony-stimulating factor dlin-mc3-dma-based formulations lipid-mediated dna-transfection procedure anti-reverse cap analog dlin-mc3-dma-formulated ilnp 2-dioleoyl-sn-glycero-3-phosphoethanolamine d-luciferin potassium salt crispr-cas gene editing pmc beta search 2-dioleoyloxy-3-trimethylammonium propane chloride n-trimethylammo- nium chloride aptamer-functionalized cationic liposome develop mrna-based therapeutics mrna-based therapeutics--developing systemic nanoparticle-mediated delivery clinically-approved ionizable lipid lipid-based nanoparticle formulations ldlr dually-independent manner tissue-specific mrna delivery exogenous ligand-based mechanisms multi-mode microplate reader low-density lipoprotein receptor fluorescence-activated cell sorting formulating cy5-labeled sirna lipid-mediated mrna delivery dlin-mc3-dma active liver-targeting transportation mrna-mediated protein expression ilp171/mrna accumulated predominantly ilp171/mrna dominantly accumulated high-efficiency sirna delivery codon-optimized coding sequence epo protein level adding enzyme substrate natural science foundation publisher site pdf mrna-encoding firefly luciferase quantitative real-time pcr codon-optimized epo mrna deliver codon-optimized mrna [google scholar] 2 fau - o'hagan author contribution cy5-fluorescence imaging data codon-unoptimized epo mrna treating liver-relative diseases final ilp171/mrna formulation ionizable lipid nanoparticle
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