
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response - PMC
Description:
Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvants immunological readouts may not be ...
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Keywords {🔍}
vaccine, mrna, doi, cells, immune, human, mimic, tlr, innate, response, cell, google, scholar, analysis, fig, activation, pubmed, gene, expression, mice, injection, rna, genes, mouse, treatment, vaccines, study, site, pmc, data, article, vitro, modules, humans, pathways, responses, dln, mimicpte, model, upregulation, skin, free, system, performed, transcriptional, phase, additional, dendritic, correlation, immunol,
Topics {✒️}
c-jun n-terminal kinase c-jun n-terminal kinases cd14low/ccr7high/hla-drhigh/cd40high/cd80high/cd86high human immunodeficiency virus deoxyribonucleic acid viral single-stranded rna double-stranded rna double-stranded structures double-stranded structure draining lymph node single-stranded rna mitogen-activated protein kinase hiv ha cluster cd draining lymph nodes retinoic acid-inducible gene lymph node map kinase hochberg false-discovery-rate method pw03-031—activation-induced cell death pattern antigen presenting cells interleukin ribonucleic acid cxc chemokine receptor single cell suspensions rnalater-preserved ln biopsies human mimic®-pte apcs plasmacytoid dendritic cells dose-dependent maturation driven [pubmed] [google scholar] prrs converge mimic® tw-pte increases messenger rna-based vaccines ssrna-receptor binding cd14low/hla-drhigh phenotype prrs leads human leukocyte antigen-dr pmc beta search gu-rich ssrna pmc copyright notice species-specific recognition clear dose-dependent increase miscellaneous immune-related genes rnalater-preserved skin biopsies human mimic®-pte modules dose-dependent maturation effect rna recognition
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