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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
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We are analyzing https://link.springer.com/article/10.1007/s10555-022-10068-w.

Title:
Natural compounds targeting nuclear receptors for effective cancer therapy | Cancer and Metastasis Reviews
Description:
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous biochemical, physiological, and pathological processes including cell survival, proliferation, differentiation, metabolism, immune modulation, development, reproduction, and aging are extensively orchestrated by different NRs. The involvement of dysregulated NRs and NR-mediated signaling pathways in driving cancer cell hallmarks has been thoroughly investigated. Targeting NRs has been one of the major focuses of drug development strategies for cancer interventions. Interestingly, rapid progress in molecular biology and drug screening reveals that the naturally occurring compounds are promising modern oncology drugs which are free of potentially inevitable repercussions that are associated with synthetic compounds. Therefore, the purpose of this review is to draw our attention to the potential therapeutic effects of various classes of natural compounds that target NRs such as phytochemicals, dietary components, venom constituents, royal jelly–derived compounds, and microbial derivatives in the establishment of novel and safe medications for cancer treatment. This review also emphasizes molecular mechanisms and signaling pathways that are leveraged to promote the anti-cancer effects of these natural compounds. We have also critically reviewed and assessed the advantages and limitations of current preclinical and clinical studies on this subject for cancer prophylaxis. This might subsequently pave the way for new paradigms in the discovery of drugs that target specific cancer types.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,542,081 visitors per month in the current month.

check SE Ranking
check Ahrefs
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How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, receptor, journal, cells, central, cell, nuclear, prostate, research, human, molecular, wang, chen, expression, lee, breast, natural, chemistry, inhibits, receptors, androgen, activity, apoptosis, growth, acid, effects, marine, activation, signaling, curcumin, letters, international, httpsdoiorg, biology, anticancer, pharmacology, liu, induces, kim, zhang, lin, yang, medicinal, estrogen, therapy,

Topics {✒️}

bt/556/ne/u-excel/2016 grant awarded pd-l1/itgb6/stat3 signaling axis mediated phosphoinositide-3-kinase/akt/mammalian target peroxisome proliferator-activated receptor-gamma attenuates tnf-alpha-mediated lipolysis bcr/abl-regulated set protein nf-kappab-regulated inflammatory cytokines acetyl-11-keto-β-boswellic acid wnt/β-catenin signaling pathway wnt/beta-catenin signaling pathways 17beta-oestradiol-treated mcf-7 cells month download article/chapter akt/mtor/s6k1 signaling cascades mitogen-activated protein kinase n-nitrosodiethylamine-induced lung tumorigenesis mir-181c-3p/pparalpha axis nf-κb-regulated gene expression nur77/hif-1alpha axis si-wu-tang series decoctions improves lps-induced inflammation natural pregnane-x-receptor agonists γ-tocopherol inhibits tumorigenesis fxr/nf-κb signalling pathway homocysteine-induced endothelial dysfunction x-ray-induced killing nf-kappab signaling pathways stat3/jak2 signaling cascade potent pregnane-x-receptor agonist thyroid-hormone receptor-mediated castration-resistant prostate cancer suppress beta-catenin signaling androgen-dependent lncap cells trans-11-conjugated linoleic acid inhibits lysosomal-dependent migration pi3k-induced ap1 cre modulates hormone-dependent transactivation neo-tanshinlactone selectively inhibits nr-mediated signaling pathways fxr-regulated bile acid inhibiting bfgf-induced lymphangiogenesis tlr4-androgen receptor axis estrogen-mediated breast cancer 26s proteasome-mediated degradation nuclear receptor-driven alterations cutaneous t-cell lymphomas nuclear-receptor interacting protein x-irradiated hela cells il-4rα-tyk2-stat6 depurinating estrogen-dna adducts pi3k/akt signaling pathway

Questions {❓}

  • Regulation of nuclear factor-kappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Schema {🗺️}

WebPage:
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         headline:Natural compounds targeting nuclear receptors for effective cancer therapy
         description:Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous biochemical, physiological, and pathological processes including cell survival, proliferation, differentiation, metabolism, immune modulation, development, reproduction, and aging are extensively orchestrated by different NRs. The involvement of dysregulated NRs and NR-mediated signaling pathways in driving cancer cell hallmarks has been thoroughly investigated. Targeting NRs has been one of the major focuses of drug development strategies for cancer interventions. Interestingly, rapid progress in molecular biology and drug screening reveals that the naturally occurring compounds are promising modern oncology drugs which are free of potentially inevitable repercussions that are associated with synthetic compounds. Therefore, the purpose of this review is to draw our attention to the potential therapeutic effects of various classes of natural compounds that target NRs such as phytochemicals, dietary components, venom constituents, royal jelly–derived compounds, and microbial derivatives in the establishment of novel and safe medications for cancer treatment. This review also emphasizes molecular mechanisms and signaling pathways that are leveraged to promote the anti-cancer effects of these natural compounds. We have also critically reviewed and assessed the advantages and limitations of current preclinical and clinical studies on this subject for cancer prophylaxis. This might subsequently pave the way for new paradigms in the discovery of drugs that target specific cancer types.
         datePublished:2022-12-08T00:00:00Z
         dateModified:2022-12-08T00:00:00Z
         pageStart:765
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            Nuclear receptors
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            Cancer Research
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               name:Chakrabhavi Dhananjaya Mohan
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               name:Sudha Warrier
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                     name:Manipal Academy of Higher Education (MAHE)
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                        name:Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
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                     name:Manipal Academy of Higher Education (MAHE)
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                     name:Humphrey Oei Institute of Cancer Research, National Cancer Centre
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      headline:Natural compounds targeting nuclear receptors for effective cancer therapy
      description:Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous biochemical, physiological, and pathological processes including cell survival, proliferation, differentiation, metabolism, immune modulation, development, reproduction, and aging are extensively orchestrated by different NRs. The involvement of dysregulated NRs and NR-mediated signaling pathways in driving cancer cell hallmarks has been thoroughly investigated. Targeting NRs has been one of the major focuses of drug development strategies for cancer interventions. Interestingly, rapid progress in molecular biology and drug screening reveals that the naturally occurring compounds are promising modern oncology drugs which are free of potentially inevitable repercussions that are associated with synthetic compounds. Therefore, the purpose of this review is to draw our attention to the potential therapeutic effects of various classes of natural compounds that target NRs such as phytochemicals, dietary components, venom constituents, royal jelly–derived compounds, and microbial derivatives in the establishment of novel and safe medications for cancer treatment. This review also emphasizes molecular mechanisms and signaling pathways that are leveraged to promote the anti-cancer effects of these natural compounds. We have also critically reviewed and assessed the advantages and limitations of current preclinical and clinical studies on this subject for cancer prophylaxis. This might subsequently pave the way for new paradigms in the discovery of drugs that target specific cancer types.
      datePublished:2022-12-08T00:00:00Z
      dateModified:2022-12-08T00:00:00Z
      pageStart:765
      pageEnd:822
      sameAs:https://doi.org/10.1007/s10555-022-10068-w
      keywords:
         Cancer
         Nuclear receptors
         Natural compounds
         Signaling molecules
         Metastasis
         Cancer Research
         Oncology
         Biomedicine
         general
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         name:Springer US
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            type:ImageObject
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      author:
            name:Mangala Hegde
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                  name:Indian Institute of Technology Guwahati
                  address:
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                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sosmitha Girisa
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
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            type:Person
            name:Nikunj Naliyadhara
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aviral Kumar
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohammed S. Alqahtani
            affiliation:
                  name:King Khalid University
                  address:
                     name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
                  name:University of Leicester
                  address:
                     name:BioImaging Unit, Space Research Centre, University of Leicester, Leicester, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohamed Abbas
            affiliation:
                  name:King Khalid University
                  address:
                     name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
                  name:Delta University for Science and Technology
                  address:
                     name:Electronics and Communications Department, College of Engineering, Delta University for Science and Technology, Gamasa, Egypt
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chakrabhavi Dhananjaya Mohan
            affiliation:
                  name:University of Mysore
                  address:
                     name:Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sudha Warrier
            affiliation:
                  name:Manipal Academy of Higher Education (MAHE)
                  address:
                     name:Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
                     type:PostalAddress
                  type:Organization
                  name:Manipal Academy of Higher Education (MAHE)
                  address:
                     name:Cuor Stem Cellutions Pvt Ltd, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kam Man Hui
            affiliation:
                  name:Humphrey Oei Institute of Cancer Research, National Cancer Centre
                  address:
                     name:Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kanchugarakoppal S. Rangappa
            affiliation:
                  name:University of Mysore
                  address:
                     name:Institution of Excellence, University of Mysore, Manasagangotri, Mysore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gautam Sethi
            url:http://orcid.org/0000-0002-8677-8475
            affiliation:
                  name:National University of Singapore
                  address:
                     name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Ajaikumar B. Kunnumakkara
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
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      volumeNumber:42
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      name:Springer US
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         name:BioImaging Unit, Space Research Centre, University of Leicester, Leicester, UK
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         name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
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         name:Electronics and Communications Department, College of Engineering, Delta University for Science and Technology, Gamasa, Egypt
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      name:University of Mysore
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         name:Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, India
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      name:Manipal Academy of Higher Education (MAHE)
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         name:Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
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         name:Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore
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         name:Institution of Excellence, University of Mysore, Manasagangotri, Mysore, India
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         name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
         type:PostalAddress
      name:Indian Institute of Technology Guwahati
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            name:Indian Institute of Technology Guwahati
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               type:PostalAddress
            type:Organization
      name:Sosmitha Girisa
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Nikunj Naliyadhara
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Aviral Kumar
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Mohammed S. Alqahtani
      affiliation:
            name:King Khalid University
            address:
               name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
            name:University of Leicester
            address:
               name:BioImaging Unit, Space Research Centre, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Mohamed Abbas
      affiliation:
            name:King Khalid University
            address:
               name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
            name:Delta University for Science and Technology
            address:
               name:Electronics and Communications Department, College of Engineering, Delta University for Science and Technology, Gamasa, Egypt
               type:PostalAddress
            type:Organization
      name:Chakrabhavi Dhananjaya Mohan
      affiliation:
            name:University of Mysore
            address:
               name:Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, India
               type:PostalAddress
            type:Organization
      name:Sudha Warrier
      affiliation:
            name:Manipal Academy of Higher Education (MAHE)
            address:
               name:Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
               type:PostalAddress
            type:Organization
            name:Manipal Academy of Higher Education (MAHE)
            address:
               name:Cuor Stem Cellutions Pvt Ltd, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
               type:PostalAddress
            type:Organization
      name:Kam Man Hui
      affiliation:
            name:Humphrey Oei Institute of Cancer Research, National Cancer Centre
            address:
               name:Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Kanchugarakoppal S. Rangappa
      affiliation:
            name:University of Mysore
            address:
               name:Institution of Excellence, University of Mysore, Manasagangotri, Mysore, India
               type:PostalAddress
            type:Organization
      name:Gautam Sethi
      url:http://orcid.org/0000-0002-8677-8475
      affiliation:
            name:National University of Singapore
            address:
               name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Ajaikumar B. Kunnumakkara
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
      name:BioImaging Unit, Space Research Centre, University of Leicester, Leicester, UK
      name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
      name:Electronics and Communications Department, College of Engineering, Delta University for Science and Technology, Gamasa, Egypt
      name:Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, India
      name:Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
      name:Cuor Stem Cellutions Pvt Ltd, Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, India
      name:Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore
      name:Institution of Excellence, University of Mysore, Manasagangotri, Mysore, India
      name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
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