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We began analyzing https://www.nature.com/articles/42750, but it redirected us to https://www.nature.com/articles/42750. The analysis below is for the second page.

Title[redir]:
A signature motif in transcriptional co-activators mediates binding to nuclear receptors | Nature
Description:
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes1,2. Ligand binding induces conformational changes in nuclear receptors and promotes their association with a diverse group of nuclear proteins, including SRC-1/p160 (3-5), TIF-2/GRIP-1 (refs 6, 7) and CBP/p300 (refs 4, 5, 8, 9) which function as co-activators of transcription, and RIP-140 (ref. 10), TIF-1 (ref. 11) and TRIP-1/SUG-1 (refs 12, 13) whose functions are unclear. Here we report that a short sequence motif LXXLL (where L is leucine and X is any amino acid) present in RIP-140, SRC-1 and CBP is necessary and sufficient to mediate the binding of these proteins to liganded nuclear receptors. We show that the ability of SRC-1 to bind the oestrogen receptor and enhance its transcriptional activity is dependent upon the integrity of the LXXLL motifs and on key hydrophobic residues in a conserved helix (helix 12) of the oestrogen receptor that are required for its ligand-induced activation function14. We propose that the LXXLL motif is a signature sequence that facilitates the interaction of different proteins with nuclear receptors, and is thus a defining feature of a new family of nuclear proteins.

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Keywords {🔍}

article, google, scholar, nature, cas, nuclear, receptors, transcriptional, receptor, ads, access, activation, content, binding, parker, cookies, proteins, coactivator, proc, natl, acad, usa, embo, protein, privacy, function, transcription, human, open, cell, sci, research, data, motif, heery, rip, tif, sequence, hormone, chambon, estrogen, factor, advertising, information, subscribe, signature, coactivators, mediates, kalkhoven, hoare,

Topics {✒️}

scientific research nature portfolio permissions reprints privacy policy advertising social media subscribe nature author information authors nature 383 nature 374 nature 370 nature 387 nature ligand-induced activation function14 anti-er monoclonal antibody differential ligand-dependent interactions author correspondence ligand-dependent activation function nuclear-receptor superfamily modifies personal data springerlink instant access human prostate cells data protection permissions human oestrogen receptor nucleic acids res gras gene family privacy common nuclear factor nuclear receptor superfamily protein–protein interactions thyroid-hormone receptor hormone-binding domains steroid-hormone receptors steroid hormone receptors activators mediates binding nuclear receptor signalling liganded nuclear receptors multiple nuclear receptors european economic area explore content subscription content transcription factor creb oncogenic protein t18 protein secondary structure transcriptional activation functions 160 kda transcriptional mediator nuclear receptors david including src-1/p160 key hydrophobic residues

Schema {🗺️}

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