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Anti-Cancer Drugs
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than monomeric artemisinin. Intracellular iron uptake is regulated by the transferrin receptor (TfR), and the activity of artemisinin depends on the availability of iron. We examined the level of TfR in prostate cancer (PCa) tumor cells, synthesized two new artemisinin dimers, and evaluated the effect of dihydroartemisinin and artemisinin dimers, ON-2Py and 2Py, on proliferation and apoptosis in PCa cells. TfR was expressed in the majority of PCa bone and soft tissue metastases, all 24 LuCaP PCa xenografts, and PCa cell lines. After treatment with dihydroartemisinin, ON-2Py, or 2Py all PCa cell lines displayed dose-dependent decrease in cell number. 2Py was most effective in decreasing cell number. An increase in apoptotic events and growth arrest was observed in the C4-2 and LNCaP cell lines. Growth arrest was observed in PC-3 cells, but no significant change was observed in DU 145 cells. Treatment with 2Py resulted in a loss of the anti-apoptotic protein survivin in all four cell lines. 2Py treatment also decreased androgen receptor and prostate-specific antigen expression in C4-2 and LNCaP cells, with a concomitant loss of cell cycle regulatory proteins cyclin D1 and c-Myc. This study shows the potential use of artemisinin derivatives as therapeutic candidates for PCa and warrants the initiation of preclinical studies....
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Keywords {🔍}
artemisinin, journal, cell, pca, cells, issue, lines, access, subscribe, alerts, submit, authors, abstract, intracellular, iron, dimers, tfr, treatment, observed, log, register, articles, issues, preclinical, effect, derivatives, apoptosis, cycle, prostate, cancer, anticancer, buy, andor, displayed, activity, receptor, dihydroartemisinin, onpy, number, growth, arrest, lncap, loss, text, subscribers, request, browse, content, service, privacy,
Topics {✒️}
plant-derived anti-malarial drug displayed anti-cancer activity anti-apoptotic protein survivin prostate-specific antigen expression journal authors submit pca cell lines lncap cell lines full text access soft tissue metastases decreasing cell number artificial intelligence training intracellular iron leading intracellular iron uptake decreased androgen receptor cell cycle service request 800-638-3030 prostate cancer cell lines register subscribe individual subscribers log journal tables cell number etoc alerts pca cells apoptotic events preclinical studies website subscribe lncap cells pca bone center submit journal transferrin receptor tumor cells pc-3 cells du 145 cells artemisinin derivatives artemisinin dimers monomeric artemisinin artemisinin depends byung juc vakar-lopez low toxicity growth arrest significant change c-myc study shows therapeutic candidates email inbox rights reserved data mining
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