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Title[redir]:
Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK - PMC
Description:
Macrophage polarization has been implicated in the pathogenesis of metabolic diseases such as obesity, diabetes, and atherosclerosis. Macrophages responsiveness to polarizing signals can result in their functional phenotype shifts. This study ...
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Keywords {🔍}
macrophages, asaronic, acid, doi, macrophage, glucose, induction, polarization, google, scholar, pubmed, activation, figure, pmc, article, free, cell, diabetic, metabolic, study, phenotype, ilrα, antibody, signaling, blot, cells, exposed, presence, arginase, stat, tissue, usa, enhanced, ngml, analysis, pathway, expression, results, inflammation, growth, bar, graphs, diabetes, high, glucoseloaded, pparγ, tgfβ, cox, mtor, absence,
Topics {✒️}
tnf-α-ros-p38mapk pathway goat anti-mouse igg il-4-mediated il-4rα induction glucose-triggered metabolic alterations glut1-mediated metabolic pathway anti-mouse igg conjugated thp-1-derived human macrophages il-4rα-tyk2-stat6 pathway donkey anti-goat igg il-4rα-tyk2-stat6 signaling determining short-term recovery lower-case alphabet letter increased il-4-il-4rα interaction akt-mtor-ampk signaling pathway tris-buffered saline-tween 20 phosphate-buffered saline-tween 20 platelet-derived growth factor disturbing tyk2-stat6 signaling ligand-activated nuclear receptor glut1-triggered metabolic aberration glut1-akt-mtor-ampk hyeongjoo glucose-induced macrophages responded pmc beta search potent anti-inflammatory properties glucose-induced m2 activation activated tyk2-stat6 pathway anti-inflammatory m2 phenotype glut1-akt-mtor-ampk pathway α-smooth muscle actin enzyme-linked immunosorbent assay glucose-primed macrophage polarization glut1-akt-mtor-ampkα activated glut1-akt-mtor-ampkα pathway agfa x-ray film m1/m2 binary classification m2-polarizing diabetic macrophages asaronic acid-bearing macrophages dose-dependently attenuated glucose-inflamed m2 macrophages il-4-activated m2 macrophages il-4-il-4rα interaction transforming growth factor-β induces human monocytes il-4-il-4 rα interaction coordinated signaling module oxidized ldl-exposed macrophages il-4-polarized m2 macrophages metabolic signaling pathways corosolic acid inhibits intracellular metabolism modulation
Questions {❓}
- Macrophage polarization in chronic inflammatory diseases: Killers or builders?
- Macrophage polarization in obesity and type 2 diabetes: Weighing down our understanding of macrophage function?
- Macrophages, lipid metabolism and geneexpression in atherogenesis: A therapeutic target of the future?
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