
DOI . ORG {
}
Title[redir]:
Anticancer potential of bioactive peptides from animal sources (Review)
Description:
Cancer is the most common cause of human death worldwide. Conventional anticancer therapies, including chemotherapy and radiation, are associated with severe side effects and toxicities as well as low specificity. Peptides are rapidly being developed as potential anticancer agents that specifically target cancer cells and are less toxic to normal tissues, thus making them a better alternative for the prevention and management of cancer. Recent research has focused on anticancer peptides from natural animal sources, such as terrestrial mammals, marine animals, amphibians, and animal venoms. However, the mode of action by which bioactive peptides inhibit the proliferation of cancer cells remains unclear. In this review, we present the animal sources from which bioactive peptides with anticancer activity are derived and discuss multiple proposed mechanisms by which these peptides exert cytotoxic effects against cancer cells.
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Keywords {🔍}
pubmedncbi, article, view, google, scholar, cells, peptides, cancer, cell, peptide, anticancer, activity, human, membrane, bioactive, cytotoxic, apoptosis, antimicrobial, isolated, growth, tumor, vitro, marine, venom, line, inhibits, mitochondrial, potential, antitumor, death, sponge, activities, studies, lines, skin, sci, chem, effects, breast, wang, specifically, reported, induces, chen, inhibit, proliferation, found, agents, pathway, carcinoma,
Topics {✒️}
activating camkii-tak1-jnk/p38 gal3-induced t-cell apoptosis frog-derived peptide hymenochirin-1b host-defense peptide hymenochirin-1b linear α-helical peptides 1021-335x online issn parp-p53-mcl-1 signaling pathway purple-sided leaf frog shrimp anti-lipopolysaccharide factor α-helical antimicrobial peptide 100-kda thomsen-friedenreich disaccharide chlorinated peptide/polyketide hybrids inhibit angiotensin-converting enzyme apoptosis-inducing factor endonuclease walnut peptide-selenium hybrids l-amino acid oxidase igf2-p4 regulatory sequences synthetic angiotensin-converting enzyme enhances uv-induced apoptosis peptide-induced membrane leakage substantial longer-term costs 80-kda iron-binding glycoprotein β-galactoside-binding lectin ph-sensitive fusogenic peptide inhibiting ikappabalpha kinase-nfkappab death receptor-induced pathways high-molecular-weight copper cd10/neutral endopeptidase expression antimicrobial peptide nk-lysin opa1-dependent cristae remodeling b16f10 tumor-bearing mice bovine meat-derived peptides home submit manuscript apoptosis-regulating protein amenable phlip-antimicrobial peptide conjugates multifunctional host-defense peptides strongest anti-proliferative activity high anti-proliferation potency apoptosis-independent phosphatidylserine externalization ap-1-dependent mmp-9 expression venom-derived peptide classified cell-selective drug delivery ef-1alpha mediates inhibition gram-negative bacteria membranes mendeley abstract cancer platelet aggregation caused anti-cancer bioactive peptide b16f10-nex2 melanoma cells inhibits xenograft growth casein fraction-derived caseinophosphopeptides
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