Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.dovepress.com/nanoencapsulation-of-natural-triterpenoid-celastrol-for-prostate-cance-peer-reviewed-fulltext-article-IJN, but it redirected us to https://www.dovepress.com/nanoencapsulation-of-natural-triterpenoid-celastrol-for-prostate-cance-peer-reviewed-fulltext-article-IJN. The analysis below is for the second page.

Title[redir]:
Nanoencapsulation of natural triterpenoid celastrol for prostate cance | IJN
Description:
Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment Vanna Sanna,1,2 Jean Christopher Chamcheu,3 Nicolino Pala,1 Hasan Mukhtar,3 Mario Sechi,1,2 Imtiaz Ahmad Siddiqui3 1Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy; 2Laboratory of Nanomedicine, University of Sassari, Sassari, Italy; 3Department of Dermatology, University of Wisconsin, Madison, WI, USA Abstract: Celastrol (CL), a triterpenoid extracted from the Chinese herb Tripterygium wilfordii, has recently attracted interest for its potential antitumor effects. However, unfavorable physicochemical and pharmacokinetics properties such as low solubility, poor bioavailability, and systemic toxicity, are limiting its therapeutic application. In this context, the development of innovative nanocarriers can be useful to overcome these issues, and nanoencapsulation would represent a powerful strategy. In this study, we developed novel CL-loaded poly(ε-caprolactone) nanoparticles (NPs), and investigated their antiproliferative efficacy on prostate cancer cells. CL-NPs were prepared using a nanoprecipitation method and fully characterized by physicochemical techniques. The antiproliferative effects on LNCaP, DU-145, and PC3 cell lines of CL-NPs, compared to those of free CL at different concentrations (0.5, 1.0, and 2.0 µM), were investigated. Moreover, fluorescence microscopy was utilized to examine the cellular uptake of the nanosystems. Furthermore, to elucidate impact of nanoencapsulation on the mechanism of action, Western analyses were conducted to explore apoptosis, migration, proliferation, and angiogenesis alteration of prostate cancer cells. The results confirmed that CL-NPs inhibit proliferation dose dependently in all prostate cancer cells, with inhibitory concentration50 less than 2 µM. In particular, the NPs significantly increased cytotoxicity at lower/medium dose (0.5 and 1.0 µM) on DU145 and PC3 cell lines with respect to free CL, with modulation of apoptotic and cell cycle machinery proteins. To date, this represents the first report on the development of biocompatible polymeric NPs encapsulating CL. Our findings offer new perspectives for the exploitation of developed CL-NPs as suitable prototypes for prostate cancer treatment. Keywords: celastrol, tripterine, nanoparticles, poly(ε-caprolactone), prostate cancer

Matching Content Categories {πŸ“š}

  • Health & Fitness
  • Science
  • Education

Content Management System {πŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month


Based on our best estimate, this website will receive around 100,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {πŸ’Έ}

We don’t know how the website earns money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {πŸ”}

nps, cancer, cell, prostate, cells, clnps, figure, celastrol, clloaded, free, nanoparticles, treatment, results, usa, proliferation, vitro, viability, potential, unloaded, growth, lines, concentrations, apoptosis, migration, concentration, protein, pcl, obtained, hours, stretching, sanna, mukhtar, siddiqui, cellular, angiogenesis, activity, drug, release, human, inhibition, abbreviations, lncap, compared, uptake, polymeric, observed, res, effects, cytotoxicity, formulation,

Topics {βœ’οΈ}

ar-erg-nf-ΞΊb pathway androgen-independent prostate cancer hormone-refractory prostate neoplasia including fast-track processing modulating osteoimmune cross-talk dove medical press baoji guokang bio-technology biorad ultraviolet-trans camera vitro anti-tumoral activity docetaxel-loaded nanoparticles based paclitaxel-loaded plga nanoparticles manuscript login white tea extract including phytochemicals/natural products androgen-independent pc3 androgen receptor [ar]-negative nanovehicle-based delivery systems stronger plc-Ξ³ expression resveratrol-loaded nanoparticles based prostate carcinoma lncap np-based therapeutic products chinese medicinal herb favored authors cl-loaded nps thermogram potent proteasome inhibitor human prostate cancer dr davide carboni green tea polyphenols green tea catechins green tea consumption increasing cl-nps concentrations specific author anti-proliferative activity androgen-dependent lncap tumor cell lines cl-nps inhibited angiogenesis controlling human cancer prostate tumor cells polyacrylamide gel electrophoresis estrogen receptor alpha cancer cell lines potential antitumor effects scanning electron microscopy trail-mediated apoptosis celastrol-loaded liposomes prostate cancer model prostate cancer cells biocompatible/biodegradable polymers dose-dependent manner protein assay kit

Questions {❓}

  • Why publish with us?

Social Networks {πŸ‘}(9)

External Links {πŸ”—}(176)

Analytics and Tracking {πŸ“Š}

  • Google Analytics
  • Google Tag Manager
  • Google Universal Analytics

Libraries {πŸ“š}

  • jQuery
  • Particles.js

Emails and Hosting {βœ‰οΈ}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {πŸ“¦}

  • Cookielaw

6.74s.