
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma - PMC
Description:
Accumulating evidence(s) indicate that CXCL12-CXCR4 signaling cascade plays an important role in the process of invasion and metastasis that accounts for more than 80% of deaths in hepatocellular carcinoma (HCC) patients. Thus, identification of ...
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Keywords {🔍}
cxcr, emodin, cells, expression, hcc, tumor, metastasis, cancer, pubmed, doi, google, scholar, nfκb, hepg, invasion, cell, assay, mice, migration, time, effect, fig, activation, results, hepb, treatment, downregulation, chemokine, shown, analysis, treated, receptor, suppresses, found, degradation, model, protein, pmc, carcinoma, orthotopic, previously, antibody, cxcl, hepatocellular, investigated, suppression, lines, tissues, control, tissue,
Topics {✒️}
n-acetyl-l-leucyl-l-leucyl-l-norleucinal p38 mapk-nf-kappab-dependent pathway tumor necrosis factor-alpha nf-κb dna-binding activity suppressing nf-κb activation constitutive nf-κb activation nf-κb regulated genes nf-κb luciferase plasmid luciferase-based reporter assay downregulate nf-κb activation enzyme-linked immunosorbent assay pmc beta search 150 mg/kg d-luciferin hrp-conjugated secondary antibodies weak cytoplasmic staining cxcr4/cxcl12 signaling cascade inhibit cxcl12-induced migration b16-f10 melanoma cells cxcl12-induced cell invasion anti-cancer agent emodin small-cell lung carcinoma nf-κb binding nf-κb activation nf-κb signaling nf-kappab activation butein inhibits growth calcium-free pbs ice-cold lysis buffer kappab-dependent transcription human hepatocellular carcinoma dna binding assay nf-kappab pathway calcium-free medium luciferase assay kit nuclear factor-kappab possess anti-inflammatory license information pmcid quantitative pcr analysis anti-p65 antibody her2-overexpressing hepg2 cells publisher site pdf cxcl12-induced migration chemokine ligand-receptor breast cancer cells corn oil-treated mice ivis™ camera system breast cancer metastasis emodin inhibits binding vivo anti-metastatic effects primary antibody anticxcr4
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