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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
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We began analyzing https://www.spandidos-publications.com/10.3892/or.2017.5495, but it redirected us to https://www.spandidos-publications.com/10.3892/or.2017.5495. The analysis below is for the second page.

Title[redir]:
Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells
Description:
Due to the anti-proliferative and anti-apoptotic effects of retinoic acid (RA), this hormone has emerged as a target for several diseases, including cancer. However, development of retinoid resistance is a critical issue and efforts to understand the retinoid signaling pathway may identify useful biomarkers for future clinical trials. Apoptotic responses of RA are exhibited through the cellular RA-binding protein II (CRABPII)/retinoic acid receptor (RAR) signaling cascade. Delivery of RA to RAR by CRABPII enhances the transcriptional activity of genes involved in cell death and cell cycle arrest. The purpose of this study was to investigate the role of curcumin in sensitizing RA-resistant triple-negative breast cancer (TNBC) cells to RA-mediated apoptosis. We provide evidence that curcumin upregulates the expression of CRABPII, RARβ and RARγ in two different TNBC cell lines. Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9. Additionally, silencing CRABPII reverses curcumin sensitization of TNBC cells to the apoptotic inducing effects of RA. These findings provide mechanistic insights into sensitizing TNBC cells to RA-mediated cell death by curcumin-induced upregulation of the CRABPII/RAR pathway.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

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🌟 Strong Traffic: 100k - 200k visitors per month


Based on our best estimate, this website will receive around 100,420 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We don’t know how the website earns money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

curcumin, cells, cancer, crabpii, cell, mdamb, pubmedncbi, article, expression, view, google, scholar, tnbc, apoptosis, retinoic, acid, pathway, caspase, growth, control, protein, rar, rarβ, breast, treatment, fig, receptor, rarγ, ramediated, atra, study, treated, crabpiirar, genes, lower, doses, parp, effects, suppression, induces, activation, level, effect, usa, death, lines, compared, res, retinoid, resistance,

Topics {✒️}

cxc-chemokine/nf-κb signalling pathway cellular ra-binding protein ii favors dmba/tpa-induced carcinogenesis peroxisome proliferator-activated receptors real-time quantitative pcr inhibiting fa/brca pathway triggers pml/raralpha degradation ra-resistant mda-mb-231 cells o-carboxymethyl chitosan nanoparticles fabp5/pparβ/δ pathway results triple-negative breast cancer retinoic acid receptor-beta mammary carcinoma mda-mb-231 home submit manuscript 1021-335x online issn retinoic acid-induced apoptosis overcoming retinoic acid-resistance skin squamous carcinogenesis fabp5/pparβ/δ pathway ra-induced growth suppression sensitize mda-mb-231 cells ra-mediated growth suppression ra-resistant tnbc cells mda-mb-231 cells compared alternative ra-resistant mechanisms human breast cancer curcumin-loaded plga nanospheres ligand binding domain mammary carcinoma growth ra-mediated cell death crabpii/rar pathway contributes regulates ra-induced apoptosis mendeley abstract due clinical oncology experimental acute promyelocytic leukemia /retinoic acid receptor retinoic acid receptor myeloma skin cancer trans-retinoic acid trans retinoic acid critical issue growth inhibitory effects mda-mb-231 cells treated mda-mb-468 cells treated diverting retinoic acid anti-goat immunoglobulin statistically reduced growth neoplastic epidermal cells glyceraldehyde 3-phosphate dehydrogenase inhibit cell growth

Questions {❓}

  • Koeffler HP: Is there a role for differentiating therapy in non-APL AML?

Social Networks {👍}(4)

External Links {🔗}(256)

Analytics and Tracking {📊}

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Libraries {📚}

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