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We began analyzing https://www.nature.com/articles/377454a0, but it redirected us to https://www.nature.com/articles/377454a0. The analysis below is for the second page.

Title[redir]:
A transcriptional co-repressor that interacts with nuclear hormone receptors | Nature
Description:
TRANSCRIPTIONAL silencing mediated by nuclear receptors is important in development, differentiation and oncogenesis1-3. The mechanism underlying this effect is unknown but is one key to understanding the molecular basis of hormone action. Here we identify a receptor-interacting factor, SMRT, as a silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors. SMRT is a previously undiscovered protein whose association with receptors both in solution and bound to DNA-response elements is destabilized by ligand. The interaction with mutant receptors correlates with their transcriptional silencing activities. In vivo, SMRT functions as a potent co-repressor, and a GAL4 DNA-binding domain fusion of SMRT behaves as a frank represser of a GAL4-dependent reporter. Together, our results identify a new class of cofactors which may be important mediators of hormone action.

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Keywords {🔍}

article, google, scholar, cas, nature, ads, access, evans, receptors, usa, cell, content, proc, natn, acad, sci, cookies, privacy, transcriptional, nuclear, data, corepressor, hormone, smrt, open, baniahmad, damm, advertising, information, journal, subscribe, chen, silencing, institution, buy, vennström, embo, tsai, molec, biol, permissions, cancer, research, optional, media, personal, parties, policy, journals, log,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising acute myeloid leukaemia social media development subscribe nature nature 374 nature 340 nature 339 nature 324 nature 318 nature 355 nature 369 nature 377 nature personal data springerlink instant access data protection permissions transcriptional silencing activities gal4-dependent reporter privacy nuclear receptor corepressors receptor-interacting factor dna-response elements mutant receptors correlates explore content subscription content nuclear hormone receptors thyroid-hormone receptors european economic area previously undiscovered protein institutional subscriptions read large-scale mapping gene expression laboratory hepatic gluconeogenesis amy accepting optional cookies don chen & ronald journals search log issue learn article chen manage preferences article purchase content article cite journal publish molecular basis silencing mediator

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