We are analyzing https://link.springer.com/article/10.1186/s40364-021-00338-0.

Title:
The role of ferroptosis in lung cancer | Biomarker Research
Description:
Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
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Keywords {🔍}

ferroptosis, pubmed, cancer, lung, google, scholar, cas, cell, cells, central, article, death, gpx, protein, slca, lipid, tumor, expression, ferroptotic, iron, degradation, res, peroxidation, activity, promotes, zhang, chen, pathway, family, including, autophagy, factor, inhibition, induces, tang, induce, system, liu, alox, gsh, yap, activation, glutathione, sensitivity, nfel, biol, role, patients, membrane, regulation,

Topics {✒️}

regulating mir-365a-3p/nrf2 axis akt/gsk3beta/n-cadherin pathway ros-mitochondrial fission-mitophagy axis oncogenic-ras-harboring cancer cells microrna-302a-3p induces ferroptosis gpx4-gss/gsr-ggt axis activity cigarette smoking-induced ferroptosis activating ca2+/calmodulin-dependent pathway cystine/glutamate transporter-deficient mice oxidative stress-induced apoptosis erastin/sorafenib induces cisplatin-resistant small-cell lung carcinoma article download pdf nicotinamide-adenine dinucleotide phosphate spermidine/spermine n1-acetyltransferase 1 small-cell lung cancer small-cell lung cancer circ0097009/mir-1261/slc7a11 axis caspase-induced protein cleavage ros-dependent cell death iron-dependent lipid peroxidation amp-activated protein kinase gsh-independent anti-ferroptosis pathways inducing epithelial-mesenchymal transition mutant yap-s127a induces ros-related cell death kras inhibitor sotorasib/amg510 mutant kras-driven signalling autophagy-dependent cell death masked nitrile-oxide electrophiles kras-mutant lung adenocarcinoma calcium/calmodulin-dependent ferroptosis evade anti-tumor immunity wild-type ras isoforms iron-dependent alox deserves polyunsaturated fatty acids-coa gsh-independent antioxidant pathway early-stage lung cancer mutant kras-mediated initiation dna primase-independent role ferroptosis-related gene signature egfr-tyrosine kinase inhibitors p53-mediated ferroptotic responses flavin-dependent mitochondrial enzyme lymphoid-specific helicase ferroptosis-resistant cell state tf-mediated iron uptake slc2a1-mediated glucose uptake tp53-activating drug apr-246 prevent hydroperoxide-induced ferroptosis

Questions {❓}

Is glutathione the major cellular target of cisplatin?

Schema {🗺️}

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         headline:The role of ferroptosis in lung cancer
         description:Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
         datePublished:2021-11-06T00:00:00Z
         dateModified:2021-11-06T00:00:00Z
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            Lung cancer
            iron
            Lipid peroxidation
            ROS
            Biomedicine
            general
            Cancer Research
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ScholarlyArticle:
      headline:The role of ferroptosis in lung cancer
      description:Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
      datePublished:2021-11-06T00:00:00Z
      dateModified:2021-11-06T00:00:00Z
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      pageEnd:14
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         Ferroptosis
         Lung cancer
         iron
         Lipid peroxidation
         ROS
         Biomedicine
         general
         Cancer Research
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               type:PostalAddress
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      affiliation:
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            address:
               name:Department of Surgery, UT Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Q. Ping Dou
      affiliation:
            name:Barbara Ann Karmanos Cancer Institute, Wayne State University
            address:
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               type:PostalAddress
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            address:
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               type:PostalAddress
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      name:Jianfei Shen
      affiliation:
            name:Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
            address:
               name:Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province
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               name:Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, China
               type:PostalAddress
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      name:Xin Chen
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      affiliation:
            name:School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University
            address:
               name:Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China
               type:PostalAddress
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PostalAddress:
      name:Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, China
      name:Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, China
      name:Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, China
      name:Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, China
      name:Department of Surgery, UT Southwestern Medical Center, Dallas, USA
      name:Department of Oncology, School of Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, USA
      name:Departments of Pharmacology & Pathology, School of Medicine, Wayne State University, Detroit, USA
      name:Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, China
      name:Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Linhai, China
      name:Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China

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